通痹活血汤治疗硼替佐米所致周围神经毒性的临床研究

Clinical Study on Tongbi Huoxue Decoction in the Treatment of Peripheral Nerve Toxicity Caused by Bortezomib

目的观察通痹活血汤预防硼替佐米治疗多发性骨髓瘤所致周围神经毒性的临床疗效。方法甄选2019年1月—2020年12月收治的多发性骨髓瘤患者42例,随机分成研究组和对照组各21例,对照组予常规对症治疗,研究组使用通痹活血汤治疗;观察2组患者神经毒性发生率和严重程度情况。结果研究组通痹活血汤疗效较好,神经毒性发生率明显低于对照组(P<0.05)。结论通痹活血汤可有效降低硼替佐米治疗多发性骨髓瘤所致的周围神经毒性的发生率。

Objective To observe the clinical effect of Tongbi Huoxue decoction in preventing peripheral neurotoxicity caused by bortezomib in the treatment of multiple myeloma.Methods 42 patients with multiple myeloma from January 2019 to December 2020 were selected and randomly divided into a study group and a control group,with 21 cases in each.The control group received conventional symptomatic treatment,and the study group received Tongbi Huoxue decoction.The incidence and severity of neurotoxicity in patients were observed.Results The study group showed better curative effect,and the incidence of neurotoxicity of the study group was significantly lower than that of the control group(P<0.05).Conclusion Tongbi Huoxue decoction can effectively reduce the incidence of peripheral neurotoxicity after bortezomib treatment of multiple myeloma.