微生态制剂辅助α-干扰素对哮喘合并肺炎支原体感染患儿免疫功能及预后的影响分析

Effect of Microecological Preparations Supplemented with Alpha-Interferon on the Immune Function and Prognosis of Children with Asthma Combined with Mycoplasma Pneumoniae Infection

目的:探讨微生态制剂辅助α-干扰素对哮喘合并肺炎支原体感染患儿免疫功能及预后的影响。方法:选择我院2020年1月至2021年8月收治的124例哮喘合并肺炎支原体感染患儿进行研究,通过随机数字表,采用简单随机方式将其分为研究组和对照组各62例,两组入院后均给予止咳、平喘、镇静等常规治疗,给予阿奇霉素治疗,对照组在此基础上接受α-干扰素雾化吸入治疗,研究组在对照组的基础上,加用微生态制剂辅助治疗,治疗5d,比较两组患儿治疗前后肺功能指标、外周血CD25、血清白细胞介素-5(IL-5)、以及总免疫球蛋白E(IgE)浓度,比较两组患儿随访期间咳嗽喘息情况。结果:治疗后两组FEV1、FVC、FEV1/FVC均高于本组治疗前(P<0.05),两组CD25、IL-5以及IgE水平均低于本组治疗前(P<0.05),且研究组治疗前后差值高于对照组(P<0.05),研究组咳嗽症状评分、平均住院时间以及随访期间喘息发生次数≥2次的例数均低于对照组,咳嗽消失时间早于对照组(P<0.05)。结论:微生态制剂辅助α-干扰素治疗哮喘合并肺炎支原体感染患儿具有理想的效果,对于改善患儿症状以及提升预后具有显著的优势,具有较好的推广前景。

Objective:To investigate the effect of microecological preparations supplemented with α-interferon on the immune function and prognosis of children with asthma complicated by Mycoplasma pneumoniae infection.Methods:A total of 124 children with asthma complicated by Mycoplasma pneumoniae infection who were admitted to our hospital from January 2020 to August 2021 were selected for study.They were randomly divided into the study group and the control group with 62 cases in each group.Both groups were given conventional treatment such as cough suppression,wheezing and sedation with azithromycin upon admission.The control group receivedα-interferon atomization inhalation therapy on the basis of this,and the study group was given probiotics adjuvant therapy on the basis of the control group.After 5 days of treatment,the pulmonary function indexes,peripheral blood CD25,serum interleukin-5(IL-5),and total immunoglobulin E(IgE)concentrations were compared between the two groups before and after treatment,and the coughing and wheezing conditions were compared between the two groups.Results:After treatment,FEV1,FVC,FEV1/FVC in the two groups were higher than those before treatment(P<0.05),CD25,IL-5 and IgE levels in the two groups were lower than those before treatment(P<0.05),and the research group The difference before and after treatment was higher than that in the control group(P<0.05).TThe cough symptom score,mean length of stay and number of wheezing episodes≥2 during follow-up were all lower in the study group than in the control group,and the cough disappeared earlier than in the control group(P<0.05).Conclusion:The microecological preparation supplemented with α-interferon in the treatment of children with asthma complicated by Mycoplasma pneumoniae infection has an ideal effect,and has significant advantages in improving the symptoms and prognosis of children,and has a good promotion prospect.