小陷胸汤合血府逐瘀汤加减治疗慢性阻塞性肺疾病疗效观察

Curative effect of Xiaoxianxiong Decoction combined with modified Xuefu Zhuyu Decoction on chronic obstructive pulmonary disease

目的观察小陷胸汤合血府逐瘀汤加减治疗慢性阻塞性肺疾病(COPD)的临床疗效。方法选取安康市中医医院2020年4月至2021年12月期间收治的90例COPD患者为研究对象,采用随机数表法分为观察组和对照组,每组45例。对照组患者给予常规治疗,观察组在此基础给予小陷胸汤合血府逐瘀汤加减治疗,两组患者均治疗两个疗程(20 d),比较两组患者的治疗效果及治疗前后的临床症状、肺功能、血气指标和不良反应发生情况。结果观察组患者的治疗总有效率为95.56%,明显高于对照组的80.00%,差异具有统计学意义(P<0.05);治疗后,观察组患者的咳嗽、咯痰、喘息、啰音、纳差的症状积分分别为(0.81±0.36)分、(0.83±0.35)分、(0.78±0.39)分、(0.35±0.15)分、(0.74±0.36)分,明显低于对照组的(1.22±0.43)分、(1.27±0.41)分、(1.24±0.48)分、(0.74±0.30)分、(1.28±0.54)分,差异均具有统计学意义(P<0.05);治疗后,观察组患者的肺功能指标用力肺活量(FVC)、一秒用力呼气容积(FEV_(1))、FEV_(1)/FVC分别为(2.72±0.52)L、(1.86±0.59)L、(68.47±6.22)%,明显高于对照组的(2.46±0.55)L、(1.43±0.63)L、(57.72±6.76)%,差异均具有统计学意义(P<0.05);治疗后,观察组患者的氧分压(PaO_(2))为(83.38±12.85)mmHg,明显高于对照组的(76.24±11.67)mmHg,二氧化碳分压(PaCO_(2))为(40.12±5.06)mmHg,明显低于对照组的(47.27±5.85)mmHg,差异均具有统计学意义(P<0.05);两组患者治疗期间均未出现恶心呕吐、腹痛等不良反应。结论小陷胸汤合血府逐瘀汤加减治疗可有效改善COPD患者的临床症状,增强肺功能,临床治疗效果好,是一项安全、有效的治疗方法。

Objective To observe the clinical effect of Xiaoxianxiong Decoction combined with modified Xuefu Zhuyu Decoction in the treatment of chronic obstructive pulmonary disease(COPD).Methods Ninety patients with COPD admitted to Ankang Hospital of Traditional Chinese Medicine from April 2020 to December 2021 were selected,which were divided into observation group and control group by random number table method,with 45 patients in each group.All patients were given conventional treatment,and patients in the observation group were additionally treated with Xiaoxianxiong Decoction combined with modified Xuefu Zhuyu Decoction.All patients were given 2 courses(20 d)of treatment.The two groups were compared on therapeutic effect,clinical symptoms,pulmonary function,blood oxygen saturation,and adverse reactions.Results The total treatment response rate of the observation group was 95.56%,significantly higher than 80.00%of the control group(P<0.05).After treatment,the scores of cough,expectoration,wheezing,rales,and anorexia in the observation group were(0.81±0.36)points,(0.83±0.35)points,(0.78±0.39)points,(0.35±0.15)points,and(0.74±0.36)points,significantly lower than(1.22±0.43)points,(1.27±0.41)points,(1.24±0.48)points,(0.74±0.30)points,and(1.28±0.54)points in the control group(P<0.05).After treatment,forced vital capacity(FVC),forced expiratory volume in 1 second(FEV_(1)),and FEV_(1)/FVC in the observation group were(2.72±0.52)L,(1.86±0.59)L and(68.47±6.22)%,significantly higher than(2.46±0.55)L,(1.43±0.63)L,and(57.72±6.76)%in the control group(P<0.05).After treatment,partial pressure of oxygen(PaO^(2))in the observation group was(83.38±12.85)mmHg,significantly higher than(76.24±11.67)mmHg in the control group(P<0.05).Thepartial pressure of carbon dioxide(PaCO_(2))was(40.12±5.06)mmHg,significantly lower than(47.27±5.85)mmHg in the control group(P<0.05).No adverse reactions such asnausea,vomiting,and abdominal pain were observed in the two groups.Conclusion Xiaoxianxiong Decoction combined with modified Xuefu Zhuyu Decoction can effectively relieve clinical symptoms and enhance pulmonary function in patients with COPD,with good clinical effect.It is a safe and effective treatment method.