阿托伐他汀对卒中后轻度认知功能障碍、神经功能恢复及脑血管储备能力的影响

Effects of atorvastatin on mild cognitive impairment,neurological recovery and cerebrovascular reserve capacity after stroke

目的探讨不同剂量阿托伐他汀治疗能否作用于脑血管储备能力机制,进而影响卒中后轻度认知功能障碍患者的认知功能水平及神经功能。方法纳入2018年5月—2020年5月期间,在本院神经内科住院的100例卒中后轻度认知障碍患者。随机分为大剂量(阿托伐他汀40 mg/d)组和小剂量(阿托伐他汀10 mg/d)组。记录半年后的简易精神状态量表(MMSE)评分、神经功能评分(NIHSS)和脑血管储备能力。结果大剂量组的MMSE评分、NIHSS评分优于小剂量组,大剂量组的脑血管储备能力改善明显,2组之间有统计学差异。脑血管储备能力提高与认知功能改善有相关性。结论大剂量阿托伐他汀治疗可明显改善卒中后轻度认知功能障碍患者的脑血管储备能力,并促进患者认知功能及神经功能恢复。

Objective To investigate whether different doses of atorvastatin can contribute to the mechanism of cerebrovascular reserve capacity,and then affect the level of cognitive function and neurological function in patients with mild cognitive impairment after stroke.Methods A total of 100 patients with mild cognitive impairment after stroke hospitalized in the department of neurology from May 2018 to May 2020 were recorded.They were randomly divided into high-dose(atorvastatin 40 mg/d)group and low-dose(atorvastatin 10 mg/d)group.The Mini-Mental State Examination(MMSE),National Institute of Health Stroke Scale(NIHSS)and cerebrovascular reserve capacity were recorded half a year later.Results The scores of MMSE and NIHSS in the high-dose group were higher than those in the low-dose group.The cerebrovascular reserve capacity of the high-dose group was significantly improved,and there was significant difference between the two groups.There was a correlation between the improvement of cerebrovascular reserve capacity and cognitive function.Conclusions High dose of atorvastatin could significantly improve the cerebrovascular reserve capacity of patients with mild cognitive impairment after stroke,and promote the recovery of cognitive function and neurological function.