血清胆红素与尿酸检验诊断冠心病的准确性

The accuracy of serum bilirubin and uric acid detection in the diagnosis of coronary heart disease

目的探究冠心病患者实施血清胆红素与尿酸检验的临床诊断价值。方法遴选时段2020年6月—2021年6月内100例冠心病患者记观察组,另择取同时段健康体检对象100例记对照组,检测血清胆红素、尿酸水平并2组相对比,同时观察组患者根据冠脉狭窄程度(Gensini法)分组为A、B、C、D组,比较冠脉不同狭窄程度分级下上述指标的变化;评估对比血清胆红素、尿酸单项指标检验与联合检验对冠心病患者的诊断效能。结果观察组较对照组血清胆红素(总胆红素、直接胆红素、间接胆红素)水平更低,尿酸水平更高,对比有统计学差异(P<0.05);随着冠脉狭窄程度越严重患者血清胆红素水平呈下降趋势,尿酸水平呈升高趋势,且4组组间比较均差异有统计学意义(P<0.05);冠心病患者血清胆红素联合尿酸检验的诊断敏感度96.00%、特异度95.00%均高于单项检验敏感度及特异度(P<0.05)。结论血清胆红素与尿酸水平可作为冠心病患者诊断的敏感性指标,其与冠心病的发生及发展密切相关,可反映患者病情严重程度,且联合检验诊断价值更高。

Objective To explore the clinical diagnostic value of serum bilirubin and uric acid detection in patients with coronary heart disease.Methods A total of 100 patients with coronary heart disease from June 2020 to June 2021 were selected as the observation group,and another 100 healthy subjects in the same period were selected as control group.Serum bilirubin and uric acid levels were detected and compared between the two groups.Meanwhile,the patients in the observation group were divided into groups A,B,C and D according to the degree of coronary artery stenosis(Gensini method).The changes of the above indexes were compared among different grades of coronary stenosis.And the diagnostic efficacy of each single detection and combined detection of serum bilirubin and uric acid in patients with coronary heart disease were evaluated and compared.Results Compared with the control group,the serum bilirubin(total bilirubin,direct bilirubin,indirect bilirubin)level of the observation group was lower,and the uric acid level was higher,with statistical differences(P<0.05).With the increased severity of coronary artery stenosis,the serum bilirubin level of patients showed a downward trend,while the uric acid level showed an upward trend,and there were significant differences among the four groups(P<0.05).The sensitivity and specificity of serum bilirubin combined with uric acid detection in patients with coronary heart disease were 96.00% and 95.00% respectively,which were higher than those of single detection(P<0.05).Conclusions Serum bilirubin and uric acid levels can be used as sensitive indicators in the diagnosis of patients with coronary heart disease,and are closely related to the occurrence and development of coronary heart disease,which can reflect the severity of the disease,also the diagnostic value of combined detection is higher.