胃高级别上皮内瘤变临床特征研究

Research on the Clinical Characteristics of Gastric High-grade Intraepithelial Neoplasia

目的探讨胃高级别上皮内瘤变(high-grade intraepithelial neoplasia,HGIN)在年龄、性别、体质指数(body mass index,BMI)、幽门螺旋杆菌感染情况、病变部位等方面的临床特征。方法回顾性分析2016年1月1日—2021年12月31日就诊我院经胃镜病理诊断为胃HGIN的患者164例。汇总患者年龄、性别、BMI、幽门螺旋杆菌感染情况、病变部位,对相关数据进行统计学处理,分析胃HGIN的临床特征。结果164例患者平均年龄(68.02±8.10)岁,≤60岁组有25例(15.24%),61~70岁组有81例(49.39%),71~80岁组有46例(28.05%),>80岁组有12例(7.32%)。男性112例(68.29%),女性52例(31.71%)。体质偏轻(BMI<18.5 kg/m^(2))组26例(15.85%),体质正常(18.5≤BMI≤23.9kg/m^(2))组98例(59.76%),体质偏重(BMI≥24 kg/m^(2))组40例(24.39%)。幽门螺旋杆菌阳性组116例(70.73%),阴性组48例(29.27%)。发生在胃窦54例(32.93%),胃角45例(27.44%),胃体37例(22.56%),胃底28例(17.07%)。结论胃HGIN患者中,发病年龄以61~70岁多见,男性发病人数多,体质正常(18.5≤BMI≤23.9kg/m^(2))组人数较多,幽门螺旋杆菌阳性多见,病变部位以胃窦多见。结合临床特征,筛选胃癌危险人群并进行内镜筛查,有助于发现早期胃癌和癌前病变,提高治疗效果。

Objective To investigate the clinical characteristics of gastric high-grade intraepithelial neoplasia(HGIN)in age,gender,body mass index(BMI),Helicobacter pylori infection and lesion site.Methods A retrospective analysis was performed on 164patients diagnosed with gastric HGIN by gastroscopy from January 1,2016 to December 31,2021 in our hospital.The age,gender,BMI,helicobacter pylori infection and lesion site of the patients were summarized,and the relevant data were statistically processed to analyze the clinical characteristics of gastric HGIN.Results The mean age of 164 patients was(68.02±8.10)years old,with 25 cases(15.24%)in≤60 years old group,81 cases(49.39%)in 61~70 years old group,46 cases(28.05%)in 71~80 years old group,and 12cases(7.32%)in>80 years old group.112 cases(68.29%)were male and 52 cases(31.71%)were female.There were 26 cases(15.85%)in the underweight group(BMI<18.5 kg/m^(2)),98 cases(59.76%)in the normal weight group(18.5≤BMI≤23.9 kg/m^(2)),and 40 cases(24.39%)in the overweight group(BMI≥24 kg/m^(2)).There were 116 cases(70.73%)in the Helicobacter pylori positive group and 48 cases(29.27%)in the Helicobacter pylori negative group.54 cases(32.93%)occurred in the gastric antrum,45 cases(27.44%)in the gastric horn,37 cases(22.56%)in the gastric body,and 28 cases(17.07%)in the gastric fundus.Conclusion In patients with gastric HGIN,the onset age was mostly 61~70 years old.The incidence was mostly male.The group with normal body weight(18.5≤BMI≤23.9 kg/m^(2))had a large number of patients.Patients with positive Helicobacter pylori was most common,and the lesion site was mostly gastric antrum.Combined with the clinical characteristics,endoscopic screening of gastric cancer high risk population can help to detect early gastric cancer and precancerous lesions and improve the therapeutic effect.