甲强龙联合红霉素治疗类百日咳综合征的临床效果分析

Clinical Effect of Methylprednisolone Combined With Erythromycin in the Treatment of Pertussis Like Syndrome

目的分析甲强龙联合红霉素治疗类百日咳综合征的临床疗效。方法选择2019年8月—2021年5月我院收治的64例类百日咳综合征患儿,随机分为对照组(n=32,给予红霉素静脉滴注,硫酸特布他林+布地奈德雾化吸入治疗)和观察组(n=32,在对照组基础上联合甲强龙静脉滴注进行治疗)。对比临床疗效、症状消失时间、吸痰次数、WBC、CRP值和不良反应。结果临床疗效,观察组96.88%高于对照组的75.00%(χ^(2)=6.335,P<0.05),临床症消失时间、住院时间,观察组短于对照组(P<0.05);吸痰次数,观察组少于对照组(P<0.05);两组治疗前的WBC、CRP水平,均差异无统计学意义(P>0.05),两组治疗后的WBC、CRP水平,都比治疗前有明显降低(P<0.05),且观察组治疗后的WBC、CRP水平低于对照组(P<0.05);不良反应发生率,观察组9.38%与对照组的6.25%差异无统计学意义(χ^(2)=0.216,P>0.05)。结论甲强龙联合红霉素治疗类百日咳综合征,可改善临床症状及实验室指标,并能够减少吸痰次数,提升整体疗效,且不会增加患儿的不良反应,治疗安全性较好。

Objective To analyze the clinical efficacy of methylprednisolone combined with erythromycin in the treatment of pertussis like syndrome.Methods 64 children with pertussis like syndrome treated from August 2019 to may 2021 were into control group(n=32,given erythromycin intravenous drip,terbutaline sulfate+budesonide aerosol inhalation)and observation group(n=32,combined with methylprednisolone intravenous drip on the basis of control group).The clinical efficacy,symptom disappearance time,sputum suction times,WBC,CRP values and adverse reactions were compared.Results In observation group,the clinical curative effect was 96.88% higher than 75.00% in control group(χ^(2)=6.335,P<0.05).The disappearance time,antipyretic time and hospitalization time of clinical symptoms such as spastic cough,shortness of breath and pulmonary rale were shorter than control group(P<0.05).The number of sputum suction was less than control group(P<0.05).There was no significant difference in the levels of WBC and CRP before treatment(P>0.05).The levels of WBC and CRP after treatment were lower than before treatment(P<0.05),and the levels of WBC and CRP in observation group were lower than control group(P<0.05).There was no difference in the incidence between observation group 9.38%and the control group 6.25%(χ^(2)=0.216,P>0.05).Conclusion Methylprednisolone combined with erythromycin in the treatment of pertussis like syndrome can take effect quickly,improve clinical symptoms and laboratory indicators,reduce the number of sputum suction,improve the overall curative effect,and will not increase the adverse reactions of children.The treatment safety is better.