背包式酶催化反应精馏制备丁酸丁酯模拟优化

Simulation and optimization process for butyl butyrate preparation by side-reactor enzyme catalytic reactive distillation

提出了背包式酶催化反应精馏合成丁酸丁酯的新工艺,将酶催化反应转移到塔外,优化了丁酸丁酯的生产过程。首先,进行丁酸乙酯与正丁醇的酯交换反应动力学实验,建立反应动力学模型,并验证该工艺流程中此模型计算结果的可靠性。然后,运用Aspen Plus对背包式反应精馏新工艺进行了流程模拟和优化设计,分别确定提馏段、精馏段的塔板数,回流比等主要参数。优化后的模拟操作条件为:精馏段塔板数5、提馏段塔板数7、回流比5、侧线循环总量6 kmol/h、侧反应器4个,此时正丁醇的反应转化率能达到99.85%,产品纯度为94.71%,有效减少了设备投资,为背包反应精馏的更优利用提供了理论依据和可行方案。

A new process of side-reactor reactive distillation was proposed for the preparation of butyl butyrate.The enzyme-catalyzed reaction was transferred out of the column to optimize the production process of butyl butyrate.Firstly,the transesterification reaction between ethyl butyrate and n-butanol was conducted in laboratory,and the reaction kinetic model was established,experiments verified the reliability of the established process calculation results.Subsequently,the new process was simulated and optimized in Aspen Plus,stage number of stripping section and rectification section,and the optimum technical parameter such as reflux ratio was determined.The optimized simulated operating conditions are as follows:the number plates of rectification section is 5,the number plates of stripping section is 7,reflux ratio is 5,circulating mole flow of side reactor is 6 kmol/h,and there are 4 side reactors.At this time,the reaction conversion of n-butanol can reach 99.85%,the product purity is 94.71%,which effectively reduces the equipment investment and provides a theoretical basis and feasible scheme for the better utilization of side-reactor reactive distillation.