中药结肠透析联合尿毒清颗粒对慢性肾脏病3~5期患者疗效及肾功能指标的影响

Curative effect of traditional Chinese medicine colon dialysis combined with Uremic Clearance Granules and its effect on renal function indexes in patients with stage 3-5 chronic kidney disease

目的探讨中药结肠透析联合尿毒清颗粒对慢性肾脏病3~5期患者疗效及肾功能指标的影响。方法选取2019年1月至2021年1月九江市第一人民医院收治的82例慢性肾脏病3~5期患者作为研究对象,采用随机数字表法将其分为常规组(41例)和研究组(41例)。常规组患者采用口服尿毒清颗粒治疗,研究组患者在常规组基础上采用中药结肠透析治疗。比较两组患者治疗前后的中医症状评分,治疗后的临床疗效,治疗前后的血尿酸(UA)、血肌酐(SCr)、血尿素氮(BUN)水平以及不良反应发生情况。结果治疗后,两组患者的主症评分、次症评分及总评分均低于治疗前,且研究组患者的主症评分、次症评分及总评分均低于常规组,差异有统计学意义(P<0.05)。研究组患者的治疗总有效率高于常规组,差异有统计学意义(P<0.05)。研究组患者的血UA、SCr、BUN水平低于常规组,差异有统计学意义(P<0.05)。两组患者治疗期间的总不良反应发生率比较,差异无统计学意义(P>0.05)。结论中药结肠透析联合尿毒清颗粒治疗慢性肾脏病3~5期患者,能够改善临床症状,提高疗效以及改善肾功能,且安全,具有一定的推广价值。

Objective To investigate the curative effect of traditional Chinese medicine colon dialysis combined with Uremic Clearance Granules effect and on the renal function indexes in patients with stage 3-5 chronic kidney disease.Methods A total of 82 patients with stage 3-5 chronic kidney disease in the First People′s Hospital of Jiujiang City from January 2019 to January 2021 were selected as the objects,and they were divided into the routine group(41 cases)and the study group(41 cases)by random number table method.The routine group was treated with oral Uremic Clearance Granules,while the study group was treated with traditional Chinese medicine colon dialysis on the basis of the routine group.Chinese medicine symptom score before and after treatment,clinical efficacy after treatment,the levels of blood uric acid(UA),serum creatinine(SCr),blood urea nitrogen(BUN)before and after treatment,and occurrence of adverse reactions were compared between the two groups.Results After treatment,the main symptom score,secondary symptom score and total score of the two groups were lower than those before treatment,and the main symptom score,secondary symptom score and total score of the study group were lower than those of the routine group,the differences were statistically significant(P<0.05).The overall treatment efficiency rate of the study group was higher than that of the routine group,the difference was statistically significant(P<0.05).After treatment,the levels of blood UA,SCr,BUN in the two groups were lower than those before treatment,and the levels of blood UA,SCr,BUN in the study group were lower than those in the routine group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of total adverse reactions during treatment between the two groups(P>0.05).Conclusion Traditional Chinese medicine colon dialysis combined with Uremic Clearance Granules in the treatment of patients with stage 3-5 chronic kidney disease can improve clinical symptoms,improve curative effect and improve renal function,which is safe and has certain popularization value.