CRP/PCT比值在鉴别肺炎支原体与肺炎链球菌感染中的应用

Application of CRP/PCT Ratio in Differentiating Mycoplasma Pneumoniae Infection and Streptococcus Pneumoniae Infection

目的 分析比较C反应蛋白(CRP)/降钙素原(PCT)比值在鉴别肺炎支原体与肺炎链球菌感染中的应用价值。方法 选取2020年1月至2021年6月我院收治的60例肺炎支原体感染患者作为肺炎支原体组,另选取同期我院收治的60例肺炎链球菌感染患者作为肺炎链球菌组,测定和比较两组患者的CRP、 PCT水平及CRP/PCT比值,绘制受试者工作特征(ROC)曲线评价CRP、 PCT、 CRP/PCT比值鉴别肺炎支原体与肺炎链球菌感染的效能。结果 肺炎支原体组的CRP、 PCT水平低于肺炎链球菌组,CRP/PCT比值高于肺炎链球菌组(P <0.05)。ROC曲线显示,CRP/PCT比值的截断值为400 mg/μg,曲线下面积(AUC)为0.92,灵敏度为95.4%,特异度为92.8%,鉴别肺炎支原体与肺炎链球菌感染的效能优于CRP、 PCT单一检测。结论 CRP/PCT比值能够准确鉴别肺炎支原体与肺炎链球菌感染,临床应用价值较高。

Objective To analyze and compare the application value of C-reactive protein(CRP)/procalcitonin(PCT) ratio in differentiating Mycoplasma pneumoniae infection and Streptococcus pneumoniae infection.Methods 60 cases of patients with Mycoplasma pneumoniae infection admitted to our hospital from January 2020 to June 2021 were selected as Mycoplasma pneumoniae group,and 60cases of patients with Streptococcus pneumoniae infection admitted to our hospital during the same period were selected as Streptococcus pneumoniae group.The CRP and PCT levels,and CRP/PCT ratio of the two groups were detected and compared,and the receiver operating characteristic(ROC) curve was drawn to evaluate the efficacy of CRP,PCT and CRP/PCT ratio in differentiating Mycoplasma pneumoniae infection and Streptococcus pneumoniae infection.Results The CRP and PCT levels of Mycoplasma pneumoniae group were lower than those of Streptococcus pneumoniae group,and the CRP/PCT ratio was higher than that of Streptococcus pneumoniae group(P <0.05).ROC curve showed that the cut-off value of CRP/PCT ratio was 400 mg/μg,the area under the curve(AUC) was 0.92,the sensitivity was 95.4%,and the specificity was 92.8%;The differentiating efficacy of Mycoplasma pneumoniae infection and Streptococcus pneumoniae infection was better than that of single detection of CRP and PCT.Conclusions CRP/PCT ratio can accurately differentiate Mycoplasma pneumoniae infection and Streptococcus pneumoniae infection,and has high clinical value.