血清25(OH)D水平与肥胖男性2型糖尿病患者合并代谢综合征的相关性

Correlation between Serum 25(OH)D Level and Metabolic Syndrome in Obese Male Patients with Type 2 Diabetes Mellitus

目的探讨血清25羟维生素D[25(OH)D]水平与肥胖男性2型糖尿病(T2DM)患者合并代谢综合征(MS)的相关性。方法选取2018年4月至2020年12月我院收治的114例肥胖男性T2DM合并MS患者作为观察组;另选取同期我院收治的114例肥胖男性T2DM患者作为对照组,统计两组患者的基线资料,并于治疗前检测血清25(OH)D水平,分析血清25(OH)D水平与肥胖男性T2DM患者合并MS的相关性。结果两组的年龄、空腹血糖、餐后2 h血糖比较差异无统计学意义(P>0.05)。观察组的体质量指数(BMI)高于对照组,血清25(OH)D水平低于对照组(P<0.05)。经Logistic回归分析结果显示,高BMI、低血清25(OH)D水平为肥胖男性T2DM患者合并MS的影响因素(OR>1,P<0.05)。结论血清25(OH)D水平与肥胖男性T2DM患者合并MS密切相关,即血清25(OH)D水平越低的肥胖男性T2DM患者越容易并发MS。

Objective To explore the correlation between serum 25 hydroxyvitamin D[25(OH)D]level and metabolic syndrome(MS)in obese male patients with type 2 diabetes mellitus(T2DM).Methods 114 obese male T2DM patients with MS admitted to our hospital from April 2018 to December 2020 were selected as the observation group.Another 114 obese male T2DM patients admitted to our hospital during the same period were selected as the control group.The baseline data of the two groups were counted,the serum 25(OH)D levels of the two groups were detected before treatment,and the correlation between serum 25(OH)D level and obese male T2DM patients with MS was analyzed.Results No statistical difference was found in the age,fasting blood glucose and 2-hour postprandial blood glucose between the two groups(P>0.05).The body mass index(BMI)of the observation group was higher than that of the control group,and the serum 25(OH)D level was lower than that of the control group(P<0.05).Logistic regression analysis showed that high BMI and low serum 25(OH)D level were the influencing factors of obese male T2DM patients with MS(OR>1,P<0.05).Conclusions Serum 25(OH)D level is closely related to obese male T2DM patients with MS.The lower the serum 25(OH)D level,the more likely obese male T2DM patients are to be complicated with MS.