妊娠晚期生殖道B族链球菌定植对母婴结局的影响

Effect of colonization of group B streptococcus in reproductive tract on maternal and infant outcomes in late pregnancy

目的探讨孕妇妊娠晚期阴道B族链球菌(GBS)定植对母婴结局的影响。方法回顾性选取2019年1月至12月北京市顺义区妇幼保健院产科分娩妊娠晚期孕妇诊断链球菌感染的106例患者作为观察组,随机选取同期GBS阴性的112例孕妇作为对照组。比较分析两组的围产期情况、抗生素使用情况及母婴结局。结果两组孕妇在胎膜早破、羊水粪染、剖宫产、产后即时出血及产褥贫血方面比较,差异无统计学意义(P>0.05)。观察组在分娩前抗生素使用情况高于对照组,差异有统计学意义(P<0.05)。两组单纯分娩后应用抗生素情况比较,差异无统计学意义(P>0.05)。观察组新生儿感染发生率及达住院标准情况高于对照组,差异有统计学意义(P<0.05)。两组新生儿高胆红素血症、结膜炎、低出生体重儿及巨大儿发生率比较,差异无统计学意义(P>0.05)。结论孕母GBS感染会增加新生儿患感染性疾病的可能,增加新生儿住院的可能性。故应对孕晚期孕妇常规进行GBS感染筛查并进行及时有效治疗,减少新生儿并发症的可能性。

Objective To investigate the effect of vaginal group B Streptococcus(GBS)colonization on maternal and infant outcomes in late pregnancy.Methods A total of 106 pregnant women diagnosed with Streptococcal infection in late pregnancy who delivered in the Obstetrics Department of Shunyi Maternal and Children’s Hospital of Beijing Children’s Hospital from January to December 2019 were retrospectively selected as the observation group,and 112 pregnant women with negative GBS during the same period were randomly selected as the control group.The perinatal conditions,antibiotic use and maternal and infant outcomes of the two groups were compared and analyzed.Results There were no significant differences in premature rupture of membranes,meconium stained amniotic fluid,cesarean section,immediate postpartum bleeding and puerperal anemia between the two groups(P>0.05).The use of antibiotics in the observation group before delivery was higher than that in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in antibiotic use after delivery between two groups(P>0.05).The infection and hospitalization rate of neonates in observation group were higher than those in the control group,the differences were statistically significant(P<0.05).There were no significant differences in incidence rates of neonatal hyperbilirubinemia,conjunctivitis,low birth weight and macrosomia between the two groups(P>0.05).Conclusion Infection of GBS in pregnant women will increase infection in newborns and possibility of hospitalization.Routine screening for GBS infection and early treatment should be condu cted to decrease neonatal complications.