基于微流控芯片的胚胎体外培养研究进展

Advancements on in vitro culture of embryo based on microfluidic chip

胚胎体外培养是辅助生殖技术的一个关键环节,胚胎培养过程中理化环境的变化会影响胚胎质量。近年来,一种基于微流控芯片的胚胎动态培养以其强大的微流体和微小物质控制能力,可以显著改善胚胎的发育潜能,成为研究胚胎体外培养的新颖且有效方法,这是传统静态微液滴培养法所不能企及的。本文就微流控芯片技术应用于胚胎体外培养的最新研究进展进行了综述。

In vitro culture(IVC)of embryo is the focus of assisted reproductive technology.Changes in the physical and chemical environment during embryo culture will affect the quality of embryo.In recent years,a dynamic IVC method based on microfluidic chips,with the powerful capability in microfluidic and micro-substance control,can significantly ameliorate the developmental potential of embryos,and it has become a novel and effective method for the study on the IVC of embryo,which has obvious advantages compared with the traditional static micro-drop culture method.This article reviews the latest research progress of microfluidic chip technology applied to the IVC of embryo.