摘要
Liver transplantation(LTx)is an established option for the treatment of end-stage liver disease,acute liver failure,and hepatic malignancies(1-3).Despite significant advances in clinical practice and scientific research on LTx,liver allograft dysfunction remains a significant clinical problem.Early allograft dysfunction(EAD)is a milder form of primary graft dysfunction that correlates with postoperative complications,higher mortality rates,and decreased graft survival(4).The frequency of EAD ranges from 15%to 30%after LTx from donors after brain death(DBD),reaching 68.4%after LTx from donors after cardiac death(DCD)(5).For living donor liver transplantation(LDLT),the prevalence of EAD is comparatively low,accounting for 18.1%of the recipients in our transplant center(4).
基金
the Sichuan Science and Technology Program(No.2019YFG0036)
the Sichuan Province Key Research and Development Project(No.2020YFS0134)
the Major National Science and Technology Special Projects(No.2017ZX10203205-005-002 and No.2017ZX10203205-001-004)
the National Natural Science Foundation of China(No.81470037 and No.81770653).
