Novaferon Effectively Inhibits Ancestral SARS-CoV-2 and Omicron Variant in Vitro,2022

Introduction:To identify Novaferon(Nova),a novel recombinant protein of interferon(IFN)-α,antiviral activity against ancestral severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and Omicron variant in vitro.Methods:Vero cells were infected with SARSCoV-2 and Omicron variant in a biosafety level-3 laboratory.And viral replications were accessed using quantitative real-time reverse transcription polymerase chain reaction(RT-PCR).Results:Results demonstrated that Nova has effective inhibition against ancestral SARS-CoV-2 and Omicron variant in vitro.Discussion:The in vivo effects of Nova need to be further tested in animal models.And large-scale randomized double-blind clinical trials are needed to reveal its potentially clinical application.