阿立哌唑联合奥氮平对双相情感障碍躁狂发作患者认知功能及炎症因子水平的影响

Effect of aripiprazole tablets combined with olanzapine tablets on cognitive function and serum inflammatory factors in patients with bipolar disorder

目的探讨阿立哌唑片联合奥氮平片对双相情感障碍躁狂发作患者认知功能及血清白细胞介素(IL-1β)、肿瘤坏死因子-α(TNF-α)、白细胞介素(IL-10)水平的影响。方法选取104例双相情感障碍躁狂发作患者,根据随机数字表法分为观察组和对照组,各52例。对照组给予阿立哌唑片治疗,观察组在对照组基础上联合应用奥氮平片。比较两组贝克-拉范森躁狂量表(BRMS)、生活质量健康状况调查简表(SF-36)、临床疗效、认知功能评分以及血清炎症因子水平。结果治疗后观察组BRMS得分明显低于对照组,SF-36得分明显高于对照组(t分别=-3.02、3.18,P均<0.05);观察组临床总有效率高于对照组(χ^(2)=5.28,P<0.05);治疗后观察组持续应答数、持续错误数、错误应答数低于对照组,完成分类数高于对照组(t分别=-4.10、-3.50、-2.67、7.39,P均<0.05);治疗后观察组血清IL-1β、TNF-α水平均明显低于对照组,IL-10水平明显高于对照组(t分别=-3.14、-2.96、2.76,P均<0.05)。结论双相情感障碍躁狂发作患者采用阿立哌唑联合奥氮平治疗,疗效确切,可有效改善其血清炎症因子水平以及认知功能,进一步提高患者生活质量。

Objective To explore the effect of aripiprazole tablets combined with olanzapine tablets on the cognitive function and serum interleukin-1β(IL-1β),tumor necrosis factorα(TNF-α),and interleukin-10(IL-10)levels in pa-tients with manic episodes of bipolar disorder.Methods One hundred and four patients with bipolar disorder were divid-ed into observation group and control group according to the random number table,with 52 cases each.The control group was treated with aripiprazole tablets,and the observation group received combined olanzapine tablets additionally.The scores of BRMS and SF-36,clinical efficacy,cognitive function scores,and serum inflammatory factor levels between two groups were compared.Results After treatment,the BRMS score of the observation group was significantly lower than the control group,the SF-36 score was significantly higher than the control group(t=-3.02,3.18,P<0.05).The total clin-ical efficiency of the observation group was higher than that of the control group(χ2=5.28,P<0.05).After treatment,the numbers of sustained response,persistent error,and error response in the observation group were less than those in the control group,while the number of completed categories was more than the control group(t=-4.10,-3.50,-2.67,7.39,P<0.05).The IL-1β,TNF-αlevels in the observation group were significantly lower than those in the control group,but the IL-10 level was significantly higher than that in the control group after treatment(t=-3.14,-2.96,2.76,P<0.05).Conclusion The therapeutic effect of aripiprazole tablets and olanzapine tablets in patients with bipolar disorder and man-ic attacks is exact,which can effectively improve their serum inflammatory factors level and cognitive function,and im-prove the quality of life of patients in further.