摘要
白藜芦醇是一种天然的多酚化合物,存在于多种植物中。其药理活性作用广泛,具有抗癌、抗氧化、抑菌、抗炎、调节免疫、保护心血管及肝脏等作用。但其水溶性差,化学稳定性低、光敏性高及生物半衰期短等缺点,极大程度地限制了其临床应用。本文回顾了近年来有关白藜芦醇的递药系统的相关研究,以期为白藜芦醇载药系统的开发利用提供参考。
As a natural polyphenolic compound,resveratrol is found in variety kinds of plants,which has many pharmacological activities,such as anti-cancer,antioxidant,antibacterial,anti-inflammatory,immune regulation,cardiovascular and liver protection.However,poor water solubility,low chemical stability,high photosensitivity and short biological half-life have seriously hindered the clinical application.Here the related research on resveratrol drug-loading delivery system in recent years were reviewed,to provide reference for the construction and application of resveratrol-loading delivery system.
作者
杨琴
王凯悦
蒲前
苏强
王娅俐
Yang Qin;Wang Kaiyue;Pu Qian;Su Qiang;Wang Yali(School of Pharmacy,North Sichuan Medical College,Nanchong 637100;Department of Pharmacy,Nanchong Central Hospital,The Second Clinical College of North Sichuan Medical College,Nanchong 637000,China)
出处
《广东化工》
CAS
2022年第14期72-74,103,共4页
Guangdong Chemical Industry
基金
川北医学院博士启动项目(编号:CBY19-QD06)
四川省中医药管理局中医药科研专项(编号:2021MS196)
四川省预防医学会第二届静脉药物配制科研项目(编号:川预学-静配-2020-012)。
关键词
白藜芦醇
生物利用度
溶解性
纳米制剂
新型载药系统
resveratrol
bioavailability
solubility
nano-preparations
novel drug-loading delivery system
