PD-L1阳性滤泡树突状细胞肉瘤一例报告并文献复习

PD-L1 Positive Follicular Dendritic Cell Sarcoma:A Case Report and Literature Review

滤泡树突状细胞肉瘤(FDCS)是起源于淋巴结或淋巴结外的滤泡性树突状细胞的罕见恶性肿瘤,WHO将其分为经典型和炎性假瘤样型,以后者更为罕见。本病无特异性临床及影像学表现,病理检查及免疫组织化学检测可以确诊。本文回顾性分析一例极其罕见的PD-L1表达阳性的原发于肝脏,后多次在结肠、胸壁及盆腔处复发的FDCS,并结合相关文献分析FDCS的临床特点及诊断、治疗方法,帮助提高临床工作者对FDCS的认识。

Follicular dendritic cell sarcoma(FDCS)is a rare malignant tumor that originates from lymph nodes or follicular dendritic cells outside the lymph nodes.The WHO classified FDCS into classic type and inflammatory pseudotumor-like type,of which the later is rarer.FDCS has no specific clinical and imaging findings and diagnosed by pathological examination and immunohistochemical tests.This article retrospectively analyzes an extremely rare case of FDCS with positive PD-L1 expression that originated in the liver and recurred in the colon,chest wall and pelvis,and combined with relevant literature to analyze the clinical characteristics,diagnosis and treatment of FDCS to help improve clinicians'awareness of FDCS.