法舒地尔联合标准化抗心衰治疗对心衰患者心功能及BNPhs-CRP ET-1ANP的影响

Effects of Fasudil Combined with Standardized Anti-HF Treatment on Cardiac Function and BNP hs-CRP ET-1 ANP in Heart Failure Patients

目的分析心衰患者联合使用法舒地尔、标准化抗心衰治疗对其心功能以及BNP、hs-CRP、ET-1、ANP等指标的影响。方法在2020年10月至2021年1月期间选出62例符合试验要求的心衰患者,采用抽签法将其均分成2组。其对照组仅实施标准化抗心衰治疗,观察组则联合使用法舒地尔、标准化抗心衰治疗,分析各组患者心功能指标、BNP水平、hs-CRP水平、ET-1水平、ANP水平、治疗有效率、不良反应发生率。结果心功能指标水平,治疗前两组差异无统计学意义(P>0.05),治疗后观察组低于对照组,差异有统计学意义(P<0.05);BNP水平、hs-CRP水平、ET-1水平、ANP水平,治疗前两组差异无统计学意义(P>0.05),治疗后观察组低于对照组,差异有统计学意义(P<0.05);治疗有效率,观察组高于对照组,差异有统计学意义(P<0.05);不良反应发生率,观察组低于对照组,差异有统计学意义(P<0.05)。结论心衰患者联合使用法舒地尔、标准化抗心衰治疗效果显著,不仅能改善病人的心功能,还能有效降低BNP、hs-CRP、ET-1、ANP等水平,值得应用。

Objective To analyze the effect of the combined fasudil and standardized anti-heart failure treatment on their heart function and BNP,hs-CRP,ET-1 and ANP.Methods 62 patients with heart failure meeting the trial requirements between October 2020 and January 2021 were selected and all divided into 2 groups by lottery.The control group only implemented standardized anti-heart F treatment,while the observation group combined fasul and standardized anti-heart F treatment,The indexes of cardiac function,BNP level,hs CRP level,ET-1 level,ANP level,treatment efficiency and incidence of adverse reactions were analyzed.Results Cardiac function index level,There was no significant difference between the two groups before treatment(P>0.05),After treatment,the observation group was lower than the control group,The difference was statistically significant(P<0.05);BNP level,hs CRP level,ET-1 level,ANP level,There was no significant difference between the two groups before treatment(P>0.05),After treatment,the observation group was lower than the control group,The difference was statistically significant(P<0.05);Treatment efficiency,The observation group was higher than the control group,The difference was statistically significant(P<0.05);Incidence of adverse reactions,The observation group was lower than the control group,The difference was statistically significant(P<0.05).Conclusion The combination of fasudil and standardized antiHF in heart failure patients can not only improve the cardiac function,but also effectively reduce BNP,hs-CRP,ET-1 and ANP,which is worth application.