阴道镜活检联合TCT检测在宫颈癌筛查中应用价值分析

The Value of Colposinal Biopsy and TCT Test in Cervical Cancer Screening

目的探讨阴道镜下宫颈活检联合宫颈液基薄层细胞学(TCT)检测在宫颈癌筛查中的诊断价值。方法选取2018年至2020年于我院行宫颈筛查的女性108例作为研究对象。所有入选者均行TCT检测、阴道镜下宫颈活检,任意一项阳性者行病理学检查,并将CINⅠ期及以上视为阳性,正常及宫颈炎视为阴性。比较不同检测方法阳性检出率、诊断效能。结果108例宫颈筛查女性中,阴道镜下宫颈活检阳性50例,TCT阳性56例,联合检测阳性71例,阳性率分别为46.30%、51.85%、65.74%;病理学诊断71例阳性患者中69例为真阳性,2例真阴性;联合检测阳性率为65.74%,高于阴道镜下宫颈活检的46.30%、TCT检测的51.85%,差异有统计学意义(P<0.05);联合检测灵敏度、准确度及阴性预测值为(100%、98.15%、100%),高于阴道镜下宫颈活检的(69.57%、78.70%、63.79%)、TCT检查的(76.81%、82.41%、69.23%),差异有统计学意义(P<0.05)。结论阴道镜下宫颈活检联合TCT检测在宫颈癌筛查中具有较高灵敏度、准确度,可进一步提高阳性检出率,便于及早发现宫颈癌变,改善患者预后。

Objective To investigate the diagnostic value of colpososcopic cervical biopsy and cervical fluid-based thin-layer cytology(TCT)detection in cervical cancer screening.Methods 108 women were cervical screened in our hospital from 2018 to 2020.All candidates underwent TCT test,colpososcopic cervical biopsy,any positive person underwent pathology,and treated phase CINⅠand above as positive,normal and cervicitis as negative.Comparing the positive detection rate and diagnostic efficacy of different testing methods.Results Among 108 women with cervical screening,Colposinal cervical biopsy was positive for 50 cases,TCT-positive for 56 cases,Combined tests tested positive for 71 cases,The positive rate were 46.30%,51.85%and 65.74%respectively;Pathological diagnosis of 69 of 71 positive patients was truly positive,Two cases were true negative;The combined test positive rate was 65.74%,Higher than 46.30%of cervical biopsy under colposscope and 51.85%of TCT,Differdifference are significant(P<0.05);The combined sensitivity,accuracy,and negative prediction values are(100%,98.15%,100%),Higher than cervical biopsy(69.57%,69.7%,78.70%,63.79%),TCT(76.81%,82.41%,69.23%),The differences is statistically significant(P<0.05).Conclusion Colposinal cervical biopsy and TCT testing have high sensitivity and accuracy in cervical cancer screening,which can further improve the positive detection rate,facilitate the early detection of cervical cancer changes,and improve the prognosis of patients.