环孢素A联合康力龙治疗慢性再生障碍性贫血的效果研究

Effect of Cyclosporin A Combined with Coriclone in the Treatment of Chronic Aplastic Anemia

目的研究环孢素A联合康力龙治疗慢性再生障碍性贫血的效果。方法选取2016年1月至2020年12月期间我院慢性再生障碍性贫血患者64例,根据随机数字表法分成单一用药组(n=32)和联合用药组(n=32),单一用药组采用康力龙,联合用药组在单一用药组的基础上采用环孢素A。对比两组疗效、治疗前后网织红细胞绝对值及血常规指标[血红蛋白(HGB)、血小板(PLT)]变化。结果联合用药组总有效率93.75%(30/32)较单一用药组68.75%(22/32)高(P<0.05);与单一用药组相比,治疗后,联合用药组网织红细胞绝对值较高(P<0.05);与单一用药组相比,治疗后,联合用药组HGB、PLT较高(P<0.05)。结论环孢素A联合康力龙治疗慢性再生障碍性贫血可以增强疗效,改善骨髓造血功能和血细胞水平。

Objective To study the effect of cyclosporin A combined with coriclone in the treatment of chronic aplastic anemia.Methods In January 2016 to 2020 were divided into randomized digital drug group(n=32)and(n=32),single drug group and cyclosporin A.Based on a single drug group changes of efficacy,absolute value of mesh red blood cells and blood routine indexes[hemoglobin(HGB),platelet(PLT)].Results The total efficiency of 93.75%(30/32)was higher than 68.75%(22/32)(P<0.05),the combined group compared with the single group(P<0.05),and HGB,PLT(P<0.05).Conclusion Cyclosporin A combined with coron for chronic aplastic anemia can enhance the efficacy and improve hematopoietic function and blood cell level.