“培土化源法”论治糖尿病皮肤瘙痒症临床疗效观察

Clinical efficacy observation on diabetic pruritus by‘banking up earth to transform source’

目的:探讨“培土化源法”论治糖尿病皮肤瘙痒症的临床疗效及安全性。方法:选取惠州市中心人民医院就诊的糖尿病皮肤瘙痒症患者80例,随机分为观察组和对照组,各40例,两组均予糖尿病基础治疗,对照组加予氯雷他定片,观察组加予甘草泻心汤加减,比较两组临床疗效、皮肤瘙痒症状积分、血糖水平、白细胞介素-6(I L-6)与总免疫球蛋白E(IgE)以及不良反应发生率。结果:观察组总有效率(100.00%,40/40)显著优于对照组(85.00%,34/40)(P<0.01)。与治疗前比较,两组患者治疗后皮肤瘙痒症状积分、IL-6、IgE均显著下降(P<0.01),且观察组显著低于对照组(P<0.01)。两组患者治疗后血糖水平比较差异无统计学意义。观察组不良反应发生率(2.5%,1/40)显著低于对照组(17.5%,7/40)(P<0.05)。结论:“培土化源法”论治糖尿病皮肤瘙痒症可明显改善瘙痒症状,降低西药不良反应,其机制可能与减少血清IL-6、IgE相关。

Objective:To discuss the clinical efficacy and safety of‘banking up earth to transform source’(Peitu Huayuan)in treating diabetic pruritus.Methods:A total of 80 patients with diabetic pruritus in Huizhou Municipal Central Hospital were selected and divided randomly into two groups:control group and observation group,40 caces in each group.On the basis that both groups were received basic diabetes treatment,control group was also received loratadine tablets orally,while observation group was received Gancao Xiexin Decoction.Comparison was made on clinical efficacy,skin pruritus scores,glycemic status,interleukin-6(IL-6),total immunoglobulin E(IgE)and incidence of adverse reactions of both groups.Results:The total effective rate of observation group(100.00%,40/40)was significantly better than the one of control group(85.00%,34/40)(P<0.01).The skin pruritus scores,IL-6,IgE of both groups were significantly decreased after treatment compared with the ones before treatment(P<0.01),while observation group was significantly lower than control group(P<0.01).The difference in glycemic status of both groups after treatment was not statistically significant.The incidence of adverse reactions of observation group(2.5%,1/40)was significantly lower than the one of control group(17.5%,7/40)(P<0.05).Conclusion:The treatment of diabetic pruritus by‘banking up earth to transform source’can significantly relieve the symptoms of pruritus and reduce the adverse reactions from Western medicine.The mechanism may be related to the reduction of IL-6 and IgE in serum.