易发带状疱疹后遗神经痛的中医体质与危险因素调查研究

Study on the constitution of traditional Chinese medicine and risk factors of neuralgia after herpes zoster

目的:调查分析易发带状疱疹后遗神经痛(PHN)的中医体质和可疑危险因素,尽早干预,以达到减少PHN患病率。方法:收集带状疱疹(HZ)患者,填写病例收集表,随访3个月,将3个月后仍有疼痛等症状的病例分为PHN组,反之为HZ组。统计全部病例的资料,将两组资料进行单因素分析,对于有统计学意义的因素再行Logistic回归分析。结果:皮损面积、汉密尔顿抑郁量表(HAMD)等级、服药依从性良好、瘀血质、气郁质、中医体质等22个因素,差异比较有统计学意义(P<0.05)。结论:皮损面积越大、HAMD等级越高、中医体质偏于血瘀质和气郁质是PHN患病的危险因素,服药依从性良好是PHN患病的保护性因素。

Objective:To investigate and analyze the constitution of traditional Chinese medicine(TCM)and suspicious risk factors of post-herpetic neuralgia(PHN),and to intervene as soon as possible,so as to reduce the prevalence of PHN.Methods:The herpes zoster(HZ)patients were collected,the case collection form were filled,followed up for 3 months,divided the patients who still had pain and other symptoms after 3 months into PHZ group,and the rest were HZ group.The data of all cases were counted,and the two groups of data were separately analyzed by single factor,and Logistic regression analysis was performed for the statistically significant factors.Results:Factors such as skin lesion area,HAMD grade,medication compliance,blood stasis constitution,qi depression constitution and TCM constitution type were statistically significant(P<0.05).Conclusion:The larger area of skin lesions and the higher level of HAMD,the more blood stasis and qi depression are the risk factors of PHN,and good compliance with medicine is the protective factor.