摘要
Cardiovascular diseases(CVDs)are the leadingcauses of death and disability worldwide,despite thewide diversity of molecular targets identified and thedevelopment of therapeutic methods.MicroRNAs(miRNAs)are a class of small(about 22 nucleotides)non-codingRNAs(ncRNAs)that negatively regulate gene expressionat the post-transcriptional level in the cytoplasm and playcomplicated roles in different CVDs.While miRNA overexpression in one type of cell protects against heartdisease,it promotes cardiac dysfunction in another typeof cardiac cell.Moreover,recent studies have shown that,apart from cytosolic miRNAs,subcellular miRNAs suchas mitochondria-and nucleus-localized miRNAs aredysregulated in CVDs.However,the functional propertiesof cellular-and subcellular-localized miRNAs have notbeen well characterized.In this review article,by carefullyrevisiting animal-based miRNA studies in CVDs,we willaddress the regulation and functional properties ofmiRNAs in various CVDs.Specifically,the cell–cellcrosstalk and subcellular perspective of miRNAs arehighlighted.We will provide the background for attractivemolecular targets that might be useful in preventing theprogression of CVDs and heart failure(HF)as well asinsights for future studies.
基金
This work was supported by grants from the National Natural Science Foundation of China(nos.81822002,91439203,91839302,81630010,31771264,81790624,82170273,and 31800973).
