综合疗法联合平阳霉素硬化剂注射对儿童大囊型淋巴管畸形的效果观察

The therapeutic effects of two methods on large cystic lymphatic malformation in children

目的探讨两种方法治疗儿童大囊型淋巴管畸形的疗效。方法将79例大囊型淋巴管畸形患儿分为试验组(n=39)和对照组(n=40),试验组应用聚桂醇泡沫硬化联合平阳霉素、半导体激光、局部弹力绷带加压的方法治疗。对照组应用平阳霉素注射方法治疗。术后随访18个月。结果治疗6个月后,2组有效率比较,差异无统计学意义(P>0.05);试验组治疗总次数、平均治疗次数低于对照组,手术时间高于对照组,差异均有统计学意义(P<0.05);2组住院天数比较,差异无统计学意义(P>0.05);试验组不良反应及不良反应发生率低于对照组,差异有统计学意义(P<0.05);2组术后白细胞较治疗前升高(P<0.05),但2组间比较差异无统计学意义(P>0.05),2组术后淋巴细胞、肝功能无明显变化(P>0.05)。结论聚桂醇泡沫硬化联合平阳霉素、半导体激光、局部弹力绷带加压和单纯注射平阳霉素治疗淋巴管畸形都是有效的方法,但前者治疗效率更高,副作用发生率更低。

Objective To investigate the therapeutic effects of two methods on large cystic lymphatic malformation in children.Methods A total of 79 children patients with large cystic lymphatic malformation were divided into experimental group(n=39)and control group(n=40).The patients in experimental group were treated by sclerosant foam combined with bleomycinl,semiconductor laser and local elastic bandage compression,however,those in control group were treated by bleomycin injection,with 18-month follow up after operation for both groups.Results After 6-month treatment,there was no significant difference in the effective rate between experimental group and control group(100%vs 97.5%,P>0.05).There were significant differences in total treatment times,average treatment times and operation time between the two groups(P<0.05).There were no significant differences in hospitalization days between the two groups(P>0.05).The incidence rates of adverse reactions in experimental group were significantly lower than those in control group(P<0.05).Moreover the numbers of leucocyte after operation in both groups were increased,but,there were no significant differences between the two groups(P>0.05).After operation,no significant changes of lymphocyte and liver function were found in both groups(P>0.05).Conclusion Both treatment of sclerosant foam combined with bleomycinl,semiconductor laser+local elastic bandage compression and the simple bleomycin injection treatment are effective in treating large cystic lymphatic malformation in children,however,the therapeutic effects in former are more significant,with fewer incidence rate of side effects.