血常规易获得炎性指标与缺血性脑卒中的关系研究进展

Research progress on the correlation between the readily available inflammatory indexes and ischemic crrebral stroke

缺血性卒中是一种死亡率和致残率非常高的疾病。它会同时激活外周免疫和中枢免疫系统,导致血脑屏障通透性增加,激活小胶质细胞和星形胶质细胞的免疫应答,引起外周中性粒细胞、淋巴细胞、单核细胞等向中枢募集,导致严重的临床症状。因此,迫切需要新的评估疾病治疗、诊断和预后方法。目前,缺血性卒中的诊断是基于神经检查、病史和神经影像学,缺少快速和低廉的诊断测试。血常规中易获得炎性标志物可以明显反映个体体内炎症水平,已被广泛应用到脑血管病的诊断与预后中。本文旨在介绍目前关于血常规中易获得炎性标志物在缺血性卒中诊断和预后中的应用认识。

Ischemic stroke is a disease with a very high mortality and disability rate,which can activate both peripheral and central immune systems,leading to increased permeability of the blood-brain barrier,activating the immune response of microglia and astrocytes,causing peripheral neutrophils,lymphocytes,and monocytes to recruit to the center,resulting in severe clinical symptoms.Therefore,new methods for assessing disease treatment,diagnosis and prognosis are urgently needed.Currently,the diagnosis of ischemic stroke is based on neurological examination,history and neuroimaging,and there is a lack of rapid and inexpensive diagnostic tests.The readily available inflammatory indexes in routine blood test can significantly reflect the level of inflammation in individuals and have been widely used in the diagnosis and prognosis of cerebrovascular diseases.The article will review the current knowledge on the significance of readily available inflammatory indexes in the diagnosis and prognosis of ischemic cerebral stroke.