2015-2020年郑州人民医院大肠埃希菌对常用抗菌药物的敏感性分析

Survey on the Sensitivity of E.Coli on Antibacterial Drugs in Common Use(Zhengzhou People’s Hospital,2015-2020)

目的:分析2015-2020年郑州人民医院大肠埃希菌对常用抗菌药物的敏感性。方法:分析2015-2020年经临床分离获得的1319份大肠埃希菌标本的检出、来源分布情况,以及对常用抗菌药物的敏感性。结果:2015-2020年医院共分离菌株20054株,其中大肠埃希菌1319株(6.58%)。2015-2020年大肠埃希菌检出率逐年升高(4.50%<5.25%<6.23%<6.68%<7.23%<8.26%)。1319株大肠埃希菌主要来自尿液、分泌物、痰液、引流物、血液等标本,其中尿液标本中检出最多(761株,57.70%)。医院抗菌药物使用量居前4位的是左氧氟沙星、哌拉西林/他唑巴坦、美罗培南和头孢吡肟。2015-2020年大肠埃希菌对哌拉西林/他唑巴坦的敏感性呈下降趋势(P<0.05),对左氧氟沙星和美罗培南的敏感性无明显变化(P>0.05),对头孢吡肟的敏感性呈上升趋势(P<0.05)。结论:大肠埃希菌检出率呈逐年升高趋势,且耐药情况不容乐观,临床应引起重视,合理使用抗菌药物。

Objective To investigate the sensitivity of E.Coli on antibacterial drugs in common use(Zhengzhou People’s Hospital,2015-2020).Methods To trace back to the status on detect detection,source distribution of 1319specimen of E.Coli isolated clinically in the hospital from 2015to 2020,and to analyse the sensitivity of E.Coli on antibacterial drugs in common use.Results The total of isolated E.Coli were 20054strains in which E.Coli accounted for 6.58%(1319/20054),from 2015to 2020the detected rate was increasing(4.50%<5.25%<6.23%<60.68%<7.23%<8.26%),the source was from urine,secretion,sputum,drained things,and blood,etc.which was dominated by urine(761strains,57.70%);the amount of antibacterial drugs used in the hospital was ordered as 1st-4th of levofloxacin,piperacillin/tazobactam,meropenem,and cefepime,during 2015-2020the sensitivity of Ec.oli on piperacillin/tazobactam was of declined trend(P<0.05);that on cefepime,of up trend(P>0.05);that on levofloxacin and meropenem had no significant change(P>0.05).Conclusion The detected rates of E.Coli become increasing year by year,and its drug-resistance admit of no optimism,thus should to pay attention,so for rationally using the drugs.