弗莱明翰心脏研究:70年的不朽丰碑

Framingham heart study:70-year monument

弗莱明翰心脏研究(FHS)是1948年由美国国立卫生研究院资助的持续时间最长的心血管流行病学研究,旨在提高对美国冠心病流行病学的了解。FSH早期在识别冠心病和卒中的危险因素及制定冠心病风险评分方面获得了广泛认可。在21世纪则开启了以遗传和组学技术为核心的“分子流行病学”新时代,作为美国第一个和全世界最具影响力之一的心血管病流行病学研究,不仅为后续的研究及指南提供数据及理论基础,也在积极寻求预防冠心病的新方法及推进个性化治疗。主要概述FSH的背景、研究目的、研究设计及学术贡献,并对今后的研究进行展望。

The Framingham Heart Study(FHS)is the longest-running cardiovascular epidemiological study funded in 1948 by the National Institutes of Health with the aim to improve understanding of the epidemiology of coronary heart disease(CHD)in the USA.Early studies of FHS earned widespread recognition in identifying risk factors for CHD and stroke and formulating CHD risk scores.The 21st century ushered in a new era in“molecular epidemiology”centered on gene and omics technologies.The FHS not only provides the data and theory basis for subsequent studies and patient care guidelines,but also actively seeks to advanced approaches to the treatment and prevention of CHD as the first and one of the most impactful studies of CHD epidemiology in the United States and worldwide.This paper summarizes the background of FSH,research purpose,design,major contributions,and discusses its future.