创伤后应激障碍的MRS研究进展

Progress of MRS research in patients with post-traumatic stress disorder

创伤后应激障碍(PTSD)是个体面临或经历了超负荷创伤性事件后产生的一种精神应激障碍疾病。常规MRI在诊断PTSD等精神疾病方面提供的信息量很少,而氢质子磁共振波谱(1H-MRS)能够在大脑结构改变之前检测到其细微的生物化学方面改变,近年来为PTSD的研究提供了有效手段。综述MRS在PTSD研究中的重要发现和研究进展,重点介绍MRS在海马、杏仁核、前扣带回和岛叶等脑区的研究发现,并展望今后可能的研究方向。

Post-traumatic stress disorder(PTSD)is a mental stress disorder that happened in people who have experienced overloaded traumatic events.Conventional MR imaging can offer little in diagnosis of mental disorders such as PTSD,while proton magnetic resonance spectroscopy(1H-MRS),which is thought to be able to detect subtle biochemical abnormalities before changes of brain structure,has been proven as an effective technique in PTSD research in recent years.In this paper,we reviewed the important MRS findings in PTSD,focused on brain regions like hippocampus,amygdala,anterior cingulate cortex,and insula,and suggested possible directions for future research.