微生态疗法在特应性皮炎的应用及其治疗机制

Application and its therapeutic mechanism of microbiome therapy in atopic dermatitis

皮肤菌群紊乱在特应性皮炎(atopic dermatitis,AD)的发生、发展中发挥重要作用。在AD患者中,致病性金黄色葡萄球菌(Staphylococcus aureus,S.aureus)优势定植,皮肤共生菌多样性下降。微生态疗法靶向调整皮肤菌群已成为AD局部治疗的新兴策略。了解S.aureus在AD中的流行病学概况及各类毒力因子的致病机制是微生态疗法的理论基础。皮肤菌群移植、S.aureus疫苗、噬菌体及其衍生的内溶素疗法是目前主要的微生态疗法手段。本文就微生态疗法在AD中的作用机制与应用进展进行综述。

The dysbiosis of cutaneous microbiota plays a fundamental role in the flare and development of atopic dermatitis(AD).The over-colonization of pathogenic Staphylococcus aureus(S.aureus)and decrease of commensals diversity were observed in AD patients.Microbiome therapy which can precisely modulate skin flora has become an emerging strategy of topical therapy for AD.The knowledge of epidemiological profile of S.aureus in AD and the pathogenicity of various virulence factors are the theoretical basis of microbiome therapy.Cutaneous microbiota transplantation,S.aureus vaccine,phage and its derived endolysin therapy are the major methods of microbiome therapy at present.The up-to-date mechanism and application of microbiome therapy in AD was summarized in this review.