氢生物医学效应在疏解自由基氧化应激的分子机制

Molecular Mechanism of Hydrogen Biomedicine in Relieving Free Radical Oxidative Stress

氢分子(H_(2))作为有害自由基清除剂的选择性抗氧化新机制,为自由基生物医学理论研究和应用提供了新的方向。自2007年H_(2)首次被报道具有生物学效应以来,已在缺血/再灌注损伤、代谢综合征、炎症和癌症等疾病模型和人类疾病中被证实。虽然H_(2)的医学作用靶点仍存在争议,但大量的研究已证明H_(2)生物学效应具有医用气体作用和健康促进作用。系统地介绍了H_(2)对生物体及细胞调控的研究进展,阐述了H_(2)的抗氧化、抗炎和抗凋亡作用,探讨了H_(2)对线粒体和内质网的保护、细胞内信号通路的调节和免疫系统的平衡作用,以期为深入研究氢效应机制和规范氢供体应用范围提供理论依据。

The selective antioxidant mechanism of hydrogen molecular(H_(2)),as a scavenger of cytotoxic free radicals,has provided a new direction for research and application of free radical biomedical theory.Since the biological effect of H_(2) was first reported in 2007,its beneficial biological effects have been demonstrated in animal models and human diseases,including ischemia/reperfusion injury,metabolic syndrome,inflammation and cancer.Although the medical target of H_(2) is still controversial,many researches have demonstrated the medical and health promotion effect of H_(2) biomedicine.This paper systematically introduced the research progress of H_(2) regulating organisms and cellular biology deciphering its anti-oxidative,anti-inflammatory and antiapoptotic effect,and the protection of mitochondria and endoplasmic reticulum,as well as the regulation effect of intracellular signaling pathways and immune system,which amied to provide systemic knowledge for further research on the H_(2) bio-mechanism and standard application.