评定增生性瘢痕激光疗效的力学模型

Mechanical Model for Evaluating Curative Effect of Laser on Hypertrophic Scar

目的通过试验研究与数值模拟相结合,建立兔耳增生性瘢痕(hypertrophic scar,HPS)治疗过程中以激光治疗次数为自变量的力学模型,用以评估HPS的临床疗效。方法利用CO_(2)激光器建立兔耳早期HPS模型,随后进行了连续3次脉冲染料激光(pulsed dye laser,PDL)联合CO_(2)点阵激光治疗,并在每次治疗恢复后测试HPS的单轴压缩力学性能,用以拟合Ogden超弹性本构模型,得到治疗过程中HPS力学参数,并通过LM最优化算法建立HPS力学参数与激光治疗次数之间的函数关系。结果HPS力学参数随激光治疗次数的增加而增大,并逐渐趋于1个常数,即正常皮肤的力学参数;且随着激光治疗次数的增加,HPS力学参数的增幅逐渐减小,初始增幅为60%,3次治疗后降为4.09%。结论激光治疗初始疗效最明显,随着症状的减轻,激光单次疗效不再显著。

Objective To establish a mechanical model with times of laser treatment as the independent variable in treatment process of rabbit ear hypertrophic scar(HPS)by combining experimental research and numerical simulation,so as to evaluate the curative effect of HPS.Methods Firstly,the HPS model of rabbit ear was established by CO_(2)laser instrument,and then the HPS was treated for continuous three times by pulsed dye laser(PDL)combined with CO_(2)lattice laser.After each treatment,the uniaxial compressive mechanical properties of HPS were tested to fit Ogden hyperelastic model to obtain mechanical parameters of HPS during the treatment.The functional relationship between mechanical parameters of HPS and times of laser treatment was established by LM optimization algorithm.Results Mechanical parameters of HPS increased with the increase of laser treatment times,and gradually became a constant,namely,mechanical parameters of normal skin.With the increase of laser treatment times,the growth ratio of HPS mechanical parameters gradually decreased.The initial growth ratio was 60%and decreased to 4.09%after three times of treatment.Conclusions The initial curative effect of laser therapy is the most obvious,and with the relief of symptoms,the effect of single laser therapy is no longer significant.