益生菌中短链脂肪酸的合成途径及功能性研究

Synthetic pathway and functional study of short chain fatty acids in probiotics

短链脂肪酸(short chain fatty acids,SCFAs)是特定的结肠厌氧细菌发酵膳食纤维和抗性淀粉后产生的主要细菌代谢产物。可以促进细胞生长,降低肠道内环境的pH值,调节宿主肠道健康。许多研究证实益生菌对肠道菌群的调节作用及其对SCFAs含量的影响,因此益生菌中的SCFAs一直是研究的热门话题。为了深入了解SCFAs,该文对SCFAs特性、在益生菌中的分布、合成途径以及对益生菌在缓解疾病中的作用进行了综述。旨在为产SCFAs的益生菌在食品以及保健品应用提供理论依据和研究思路。

Short chain fatty acids(SCFAs)are the main bacterial metabolites,which are produced by specific colonic anaerobic bacteria after fermentation of dietary fiber and resistant starch.It can promote cell growth,reduce the pH value of the intestinal environment and regulate the intestinal health of the host.Many studies have confirmed the regulatory effect of probiotics on intestinal flora and their effect on SCFAs content.Therefore,SCFAs in probiotics has always been a hot research topic.In order to gain a deeper understanding of SCFAs,this article mainly reviews the research progress on characteristics,distribution and synthetic pathways of SCFAs in probiotics and the role of probiotics in disease remission.The aim is to provide theoretical basis and research ideas for SCFAs-producing probiotics in food and health care products.