布地奈德联合维生素K3注射液治疗小儿毛细支气管炎的效果观察及对炎症因子的影响

Effect of Budesonide Combined with Vitamin K_(3)Injection in the Treatment of Bronchiolitis in Children and Its Effect on Inflammatory Factors

目的探究布地奈德联合维生素K_(3)注射液治疗小儿毛细支气管炎的效果观察及对炎症因子的影响。方法选取2020年6月至2021年11月期间河南科技大学第一附属医院收治的110例毛细支气管炎患儿,使用随机抽样法分为试验组(布地奈德联合维生素K_(3)注射液治疗)与参照组(布地奈德治疗)各55例,对比两组疗效、呼吸功能、肺功能、炎性指标。结果试验组治疗有效率为96.36%,高于参照组85.45%,差异有统计学意义(P<0.05),治疗前两组动脉血氧分压(PaO_(2))、动脉二氧化碳分压(PaCO_(2))、动脉血氧饱和度(SaO_(2))值比较,差异无统计学意义(P>0.05),治疗后试验组PaO_(2)、SaO_(2)值高于参照组,PaCO_(2)值低于参照组,差异有统计学意义(P<0.05),治疗前两组第一秒用力呼气容积(FEV1)、用力肺活量(FVC)、FEV1/FVC值比较,差异无统计学意义(P>0.05),治疗后试验组FEV1、FVC、FEV1/FVC值均高于参照组,差异有统计学意义(P<0.05),治疗前两组炎性指标比较,差异无统计学意义(P>0.05),治疗后试验组白介素-8(IL-8)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)低于参照组,差异有统计学意义(P<0.05)。结论将布地奈德联合维生素K3注射液治疗应用于小儿毛细支气管炎后,疗效确切,能促使其肺功能尽快恢复,改善炎症因子,值得应用。

Objective To investigate the effect of budesonide combined with vitamin K_(3) injection on children bronchiolitis and the effect on inflammatory factors.Methods A total of 110 children with bronchiolitis treated in the First Affiliated Hospital of Henan University of Science and Technology from June 2020 to November 2021 were randomly divided into experimental group(budesonide combined with vitamin K_(3) injection)and reference group(budesonide combined with vitamin K_(3) injection),with 55 cases in each group.The curative effect,respiratory function,lung function and inflammatory indexes were compared between the two groups.Results The effective rate of experimental group was 96.36%higher than that of the reference group(85.45%),and the difference was statistically significant(P<0.05).Before treatment,there were no statistically significant differences in arterial partial pressure of oxygen(PaO_(2)),arterial partial pressure of carbon dioxide(PaCO_(2))and arterial oxygen saturation(SaO_(2))between the two groups(P>0.05).After treatment,the PaO_(2) and SaO_(2) values in the experimental group were higher than those in the reference group,while PaCO_(2) values were lower than those in the reference group,with statistical significance(P<0.05).There were no significant differences in forced expiratory volume(FEV1),forced vital capacity(FVC)and FEV1/FVC between the two groups before treatment(P>0.05).After treatment,the values of FEV1,FVC and FEV1/FVC in the experimental group were higher than those in the reference group,the differences were statistically significant(P<0.05),while there was no significant difference in inflammatory indexes between the two groups before treatment(P>0.05).After treatment,interleukin-8(IL-8),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and hypersensitive C-reactive protein(HS-CRP)in the experimental group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion The combination of budesonide and vitamin K_(3) injection in the treatment of bronchiolitis in children has a definite curative effect,which can promote the recovery of lung function as soon as possible and improve inflammatory factors.