摘要
异基因造血干细胞移植(allogeneic hematopoietic stem cell transplantation,allo-HSCT)是许多血液系统疾病和非血液系统疾病的有效治愈方法,而allo-HSCT后感染的发病率和病死率仍较高,这与免疫细胞亚群的恢复密切相关。对自然杀伤(natural killer,NK)细胞、T细胞和B细胞亚群恢复的深入研究有助于更好地预测和调节不良事件的发生。该文将造血干细胞移植后NK细胞、T细胞和B细胞免疫重建的规律、影响因素以及它们与结果的关系作一综述。
Allogeneic hematopoietic stem cell transplantation(allo-HSCT)is an effective cure for many hematologic and non-hematologic diseases.However,infection morbidity and mortality remain high after allo-HSCT,which is closely related to the recovery of immune cell subsets.The detailed information on the recovery of natural killer(NK),T and B cell subsets can better predict and regulate the occurrence of adverse events.This article will review the current rules,influencing factors and the relationship between the outcome and the immune reconstitution of NK cells,T cells and B cells after hematopoietic stem cell transplantation.
作者
周娅(综述)
窦颖(审校)
Zhou Ya;Dou Ying(Department of Hematology Oncology,Children′s Hospital of Chongqing Medical University,National Clinical Research Center for Child Health and Disorders,Ministry of Education Key Laboratory of Child Development and Disorders,Chongqing Key Laboratory of Child Infection and Immunity,Chongqing 400014,China)
出处
《国际儿科学杂志》
2022年第5期320-324,共5页
International Journal of Pediatrics
基金
重庆市科卫联合医学科研项目 (2021MSXM112)。
关键词
异基因造血干细胞移植
免疫重建
NK细胞
T细胞
B细胞
Allogeneic hematopoietic stem cell transplantation
Immune reconstitution
NK cell
T cell
B cell
