三酰甘油葡萄糖乘积与肥胖相关指标对高血压患病风险的影响

Triglyceride-glucose index and obesity-related anthropometric indices on the risk of hypertension

目的探讨三酰甘油葡萄糖乘积(TyG)指数与肥胖指标之间的交互作用对高血压患病风险的影响。方法对上海市宝山区淞南社区3356名40岁以上的常住居民,进行问卷调查、体格检查、生化指标检测等。将腰臀比(WHR)、腰围身高比(WHtR)、体重指数(BMI)与TyG指数分别相乘,生成TyG-WHR、TyG-WHtR及TyG-BMI 3项新指标,采用logistic回归模型探究其与高血压患病风险的相关性。并分析不同性别中TyG指数与肥胖相关指标对高血压患病风险的交互作用。结果经多元校正后,与各指标最低四分位数(Q1)相比,TyG、TyG-WHR、TyG-WHtR及TyG-BMI最高四分位数(Q4)的高血压患病风险均增加,OR(95%CI)值分别为2.93(2.37~3.62)、3.22(2.59~4.01)、4.33(3.46~5.42)和4.07(3.27~5.06)。在女性中,TyG与腹型肥胖相关指标WHR(RERI=1.52,95%CI 0.12~2.92;AP=0.32,95%CI 0.06~0.59)及WHtR(RERI=2.41,95%CI 0.64~4.19;AP=0.39,95%CI 0.15~0.63;SI=1.88,95%CI 1.10~3.21)在高血压发生风险方面具有生物协同交互作用,而在男性中并未发现。结论TyG与肥胖相关指标组合后与高血压患病风险升高有显著相关性,性别及脂肪分布类型可能影响上述关系。

Objective To investigate the impact of the interaction between triglyceride-glucose(TyG)and obesity-related anthropometric indices on hypertension risk.Methods A total of 3356 permanent residents over 40 years were recruited from Songnan community,Baoshan district,Shanghai.All participants underwent questionnaire surveys,physical examinations,and biochemical parameter tests.TyG-WHR,TyG-WHtR,and TyG-BMI were obtained by multiplying TyG index with waist-to-hip ratio(WHR),waist-to-height ratio(WHtR),and body mass index(BMI),respectively.Logistic regression models were used to investigate the associations of the three indices and hypertension.The interactions of TyG index and obesity-related anthropometric indices on the risk of hypertension were analyzed in different genders.Results After multivariable adjustment,the fourth quartile of TyG,TyG-WHR,TyG-WHtR,and TyG-BMI demostrated higher risk of hypertension compared with the first quantile,with OR(95%CI)2.93(2.37-3.62),3.22(2.59-4.01),4.33(3.46-5.42),and 4.07(3.27-5.06).Two abdominal obesity-related indicators WHR(RERI=1.52,95%CI 0.12-2.92;AP=0.32,95%CI 0.06-0.59)and WHtR(RERI=2.41,95%CI 0.64-4.19;AP=0.39,95%CI 0.15-0.63;SI=1.88,95%CI 1.10-3.21)had a biological interaction with TyG index on the risk of hypertension in female,but not in male.Conclusion The combination of TyG and obesity-related indicators is significantly correlated with the increased risk of hypertension,which may be influenced by gender and fat distribution type.