血清TNF-α、TGF-β1和PSA水平与良性前列腺增生患者预后的关系

Relationship between serum TNF-α,TGF-β1 and PSA levels and prognosis of patients with benign prostatic hyperplasia

目的 探讨血清肿瘤坏死因子(TNF-α)、转化生长因子(TGF-β1)和前列腺特异抗原(PSA)水平与良性前列腺增生患者预后的关系。方法 101例良性前列腺增生患者(增生组)采用经尿道前列腺电切术(TURP)治疗,并以同期40名健康查体男性人群为健康组。检测比较两组血清TNF-α、TGF-β1和PSA水平。比较增生组术前和术后3个月的国际前列腺症状评分(IPSS)、最大尿流率、残余尿量。统计增生组术后尿路感染发生率,并分析其血清TNF-α、TGF-β1和PSA水平与术后尿路感染和预后的关系。结果 增生组术前血清TNF-α、TGF-β1和PSA水平高于健康组,差异有统计学意义(P<0.05)。与同组术前比较,增生组术后3个月的血清TNF-α、TGF-β1和PSA水平、IPSS评分和残余尿量均降低而同期最大尿流率则升高,差异有统计学意义(P<0.05)。增生组术后尿路感染发生率为14.85%(15/101),且其术后尿路感染患者术后3个月的血清TNF-α、TGF-β1和PSA水平、IPSS评分及残余尿量均高于无术后尿路感染患者而同期最大尿流率则低于无术后尿路感染患者,差异有统计学意义(P<0.05)。增生组术后尿路感染可影响术后3个月血清TNF-α、TGF-β1和PSA水平、IPSS评分、残余尿量及最大尿流率(P<0.05)。术后3个月增生组血清TNF-α、TGF-β1和PSA水平与IPSS评分、残余尿量、最大尿流率均相关(P<0.05)。结论 良性前列腺增生患者血清TNF-α、TGF-β1和PSA水平升高且与其术后尿路感染及预后均密切相关。

Objective To investigate the relationship between serum levels of tumor necrosis factor(TNF)-α,transforming growth factor(TGF)-β1 and prostate specific antigen(PSA)and prognosis of patients with benign prostatic hyperplasia. Methods 101 patients with benign prostatic hyperplasia(hyperplasia group)were treated with transurethral resection of the prostate(TURP),and 40 healthy males were selected as the healthy group during the same period. The serum levels of TNF-α,TGF-β1 and PSA between the two groups were detected and compared. The International Prostate Symptom Score(IPSS),maximum urinary flow rate and residual urine volume in the hyperplasia group before and 3 months after surgery were compared. The incidence of postoperative urinary tract infection in the hyperplasia group was counted,and the relationship between serum TNF-α,TGF-β1 and PSA levels with postoperative urinary tract infection and prognosis was analyzed.Results The preoperative serum TNF-α,TGF-β1 and PSA levels in the hyperplasia group were higher than those in the healthy group,and the difference was statistically significant(P<0.05). Compared with those of the same group before operation,serum TNF-α,TGF-β1 and PSA levels,IPSS score and residual urine volume at3 months after operation in the hyperplasia group decreased,while the maximum urinary flow rate during the same period in the hyperplasia group increased,and the difference was statistically significant(P<0.05). The incidence of postoperative urinary tract infection in the hyperplasia group was 14.85%(15/101),and,the serum TNF-α,TGF-β1 and PSA levels,IPSS score and residual urine volume of the patients with postoperative urinary tract infection at 3 months after surgery were higher than those of the patients without postoperative urinary tract infection,while the highest urine flow rate in the same period of the patients with postoperative urinary tract infection were lower than those of the patients without postoperative urinary tract infection,and the difference was statistically significant(P<0.05). Postoperative urinary tract infection in hyperplasia group could affect serum TNF-α,TGF-β1 and PSA levels,IPSS score,residual urine volume and maximum urine flow rate 3 months after operation(P<0.05). The serum levels of TNF-α,TGF-β1 and PSA in the hyperplasia group at 3 months after operation were correlated with IPSS score,residual urine volume and maximum urinary flow rate(P<0.05). Conclusion The serum levels of TNF-α,TGF-β1 and PSA were increased in patients with benign prostatic hyperplasia and were closely related to postoperative urinary tract infection and prognosis.