单纯放疗与同步放化疗治疗非早期宫颈癌患者的疗效观察

Observation on the efficacy of radiotherapy alone and concurrent radiotherapy and chemotherapy in the treatment of patients with non-early cervical cancer

目的分析非早期宫颈癌疾病特点及治疗要点,对比采用单纯放疗与同步放化疗治疗的临床效果。方法84例非早期宫颈癌患者为研究对象,随机分为对照组与观察组,各42例。对照组采用放疗治疗,观察组采用同步放化疗治疗。比较两组治疗效果、不良反应发生情况及治疗前后临床相关指标[Karnofsky功能状态(KPS)评分、生活质量量表(QOL)评分、糖类抗原125(CA125)及癌胚抗原(CEA)水平]。结果观察组治疗总有效率78.57%高于对照组的50.00%,差异有统计学意义(P<0.05)。观察组骨髓抑制、消化道反应发生率分别为66.67%、64.29%,均高于对照组的40.48%、38.10%,差异有统计学意义(P<0.05)。治疗后,观察组KPS评分(60.05±4.50)分、QOL评分(50.50±4.50)分、CEA(17.05±2.50)ng/ml及CA125(25.20±2.50)U/ml均优于对照组的(50.50±4.50)分、(40.05±4.30)分、(19.80±2.20)ng/ml及(28.80±2.30)U/ml,差异均有统计学意义(P<0.05)。结论对比单纯放疗治疗,同步放化疗治疗非早期宫颈癌效果显著,降低了患者的血清肿瘤标志物水平,提高了患者的功能状态、生活质量,但是不良反应也随之增多,需积极干预。

Objective To analyze the characteristics and treatment points of non-early cervical cancer,and compare the clinical effects of radiotherapy alone and concurrent radiotherapy and chemotherapy.Methods A total of 84 patients with non-early stage cervical cancer were selected as the research subjects,and the patients were randomly divided into the control group and the observation group,with 42 cases in each group.The control group was treated with radiotherapy,and the observation group was treated with concurrent radiotherapy and chemotherapy.Both groups were compared in terms of therapeutic effect,the occurrence of adverse reactions,and clinical related indicators[Karnofsky performance scale(KPS)score,quality of life(QOL)score,carbohydrate antigen 125(CA125)and carcinoembryonic antigen(CEA)]before and after treatment.Results The total effective rate 78.57% of the observation group was higher than 50.00% of the control group,and the difference was statistically significant(P<0.05).The incidence rates of myelosuppression and gastrointestinal reaction in the observation group were 66.67% and 64.29%,which were higher than 40.48% and 38.10% in the control group,and the difference was statistically significant(P<0.05).After treatment,the KPS score(60.05±4.50)points,QOL score(50.50±4.50)points,CEA(17.05±2.50)ng/ml and CA125(25.20±2.50)U/ml in the observation group were better than(50.50±4.50)points,(40.05±4.30)points,(19.80±2.20)ng/ml and(28.80±2.30)U/ml in the control group,and the differences were statistically significant(P<0.05).Conclusion Compared with radiotherapy alone,concurrent radiotherapy and chemotherapy are effective in treating non-early cervical cancer,and can reduce the level of serum tumor markers in patients and improve the functional status and quality of life of patients,but the adverse reactions also increase,and active intervention is required.