早产儿窒息对心肌酶谱的影响

The effect of asphyxia in premature infants on myocardial enzyme spectrum

目的研究早产儿窒息对心肌酶谱的影响,有利于临床的预防、诊断和治疗。方法选取79例窒息早产儿作为研究对象,其中15例重度窒息早产儿作为重度窒息组,64例轻度窒息早产儿作为轻度窒息组;同时选取29例非窒息早产儿作为对照组。出生后24 h内检测三组早产儿心肌酶谱指标。比较三组早产儿一般临床资料、心肌酶谱指标[肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)、α-羟基丁酸脱氢酶(α-HBDH)、谷草转氨酶(AST)]。结果三组早产儿的AST、LDH、CK-MB、α-HBDH水平比较差异具有统计学意义(P<0.05);三组早产儿的CK水平比较差异无统计学意义(P>0.05)。重度窒息组早产儿的AST、LDH、CK-MB、α-HBDH水平分别为(133.600±116.687)、(1098.733±607.213)、(233.267±205.581)、(772.333±413.405)U/L,轻度窒息组早产儿分别为(50.344±39.603)、(579.266±302.641)、(139.234±166.604)、(393.953±202.431)U/L,对照组早产儿分别为(39.450±26.307)、(468.660±130.381)、(73.210±50.408)、(302.210±82.636)U/L。重度窒息组早产儿的AST、LDH、CK-MB、α-HBDH水平高于轻度窒息组及对照组,轻度窒息组早产儿高于对照组,差异具有统计学意义(P<0.05)。结论窒息对早产儿心肌酶谱有一定的影响,对心肌及机体会造成一定损害,而CK并不是特异性指标,心肌酶谱中的各项指标要进行多方面分析。出生后对早产儿进行心肌酶谱检测有助于病情的分析、诊断与治疗,对临床工作意义重大。

Objective To study the effect of asphyxia in premature infants on myocardial enzyme spectrum,so as to help clinical prevention,diagnosis and treatment.Methods A total of 79 premature infants with asphyxia were selected as the research subjects,of which 15 premature infants with severe asphyxia were selected as the severe asphyxia group,and 64 premature infants with mild asphyxia were selected as the mild asphyxiated group;another 29 premature infants without asphyxia were selected as the control group.The myocardial enzyme spectrum indexes of the three groups of premature infants were detected within 24 h after birth.The general clinical data,myocardial enzyme spectrum indexes[creatine kinase(CK),creatine kinase isoenzyme(CK-MB),lactate dehydrogenase(LDH),α-hydroxybutyrate dehydrogenase(α-HBDH),aspartate aminotransferase(AST)]of the three groups were compared.Results The levels of AST,LDH,CK-MB andα-HBDH among the three groups of premature infants were compared,and the differences were statistically significant(P<0.05).There was no statistically significant difference in CK levels among the three groups of premature infants(P>0.05).The levels of AST,LDH,CK-MB andα-HBDH of premature infants in the severe asphyxia group were(133.600±116.687),(1098.733±607.213),(233.267±205.581),and(772.333±413.405)U/L,those of premature infants in the severe asphyxia group were(50.344±39.603),(579.266±302.641),(139.234±166.604),and(393.953±202.431)U/L,and those of preterm infants in the control group were(39.450±26.307),(468.660±130.381),(73.210±50.408),and(302.210±82.636)U/L.The levels of AST,LDH,CK-MB andα-HBDH of premature infants in severe asphyxia group were higher than those in mild asphyxia group and control group,and the differences were statistically significant(P<0.05).Conclusion Asphyxia has a certain effect on the myocardial enzyme spectrum of premature infants,and will cause certain damage to the myocardium and the body.CK is not a specific index,and various indexes in the myocardial enzyme spectrum should be analyzed in many aspects.The detection of myocardial enzyme spectrum in premature infants after birth is helpful for the analysis,diagnosis and treatment of disease,which is of great significance to clinical work.