首发抑郁症患者的生活质量与临床症状的相关性研究

Correlation between quality of life and clinical symptoms in patients with first-episode depression

目的 探讨首发抑郁症患者的生活质量与临床症状的相关性。方法 选取2020年5月~2021年5月于哈尔滨医科大学附属第一医院就诊的首发抑郁症患者46例,分为首发组(未接受药物治疗)及干预组(接受药物治疗),各23例。同时随机选取同期体检中心健康体检人员20例作为健康组。比较3组受试者基本资料、生活质量和临床量表评分。分析首发组及干预组生活质量与临床量表评分之间的相关性。结果 3组受试者教育程度、年龄、性别构成比较,差异无统计学意义(P>0.05);干预组汉密尔顿焦虑量表(Hamilton Anxiety Scale, HAMA)及蒙哥马利抑郁量表(Montgomery-Asberg Depression Rating Scale, MADRS)评分均低于首发组(P<0.05);首发组与干预组生活质量评分比较,数据无统计学差异(P>0.05);首发组与干预组生活质量评分、社会适应自我评价量表(Social Adaptation Self-Scale, SASS)评分均低于健康组,差异有统计学意义(P<0.05);首发组与干预组环境、生理及生活质量总分与汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(Hamilton Depression Scale, HAMD)及蒙哥马利抑郁量表(MADRS)评分成负相关,与社会适应自我评价量表(SASS)成正相关。结论 首发抑郁症患者抑郁症状越明显,生活质量越差;社会适应能力越好,生活质量越好。

Objective To explore the correlation between quality of life and clinical symptoms in patients with first-episode depression. Methods Forty-six patients with first-episode depression who attended the First Hospital of Harbin Medical University from May 2020 to May 2021 were selected and divided into the first-episode group(not receiving medication) and the intervention group(receiving medication), 23 cases in each group. At the same time, 20 cases were randomly selected as the health group from the health check-up center. The subjects’ basic information, quality of life, and clinical scale scores in the three groups were compared. Correlations between the quality of life and clinical scale scores were analyzed in the first-episode and intervention groups. Results The differences in educational level, age, and gender composition were not statistically significant in the three groups(P>0.05). The Hamilton Anxiety Scale(HAMA) and Montgomery-Asberg Depression Rating Scale(MADRS) scores were lower in the intervention group than in the first-episode group. There was no statistical difference in the quality of life scores between the first-episode group and the intervention group(P>0.05). The quality of life scores and Social Adaptation Self-Scale(SASS) scores in the first-episode group and intervention groups were lower than in the health group;the differences were statistically significant(P<0.05). The environmental, physical, and the total quality of life scores were negatively correlated with HAMA, Hamilton Depression Scale(HAMD), and MADRS scores and positively correlated with SASS in the first-episode and intervention groups. Conclusion The more severe the depressive symptoms in patients with first-episode depression, the worse the quality of life;the better the social adjustment, the better the quality of life.