糖尿病难愈创面的发病机制及治疗研究进展

Research progress of pathogenesis and treatment of diabetic nonhealing wounds

糖尿病创面难愈与糖代谢异常关系密切,是临床常见、治疗棘手的并发症。由于其发病机制复杂且未完全明确,临床尚缺乏安全、高效的治疗方法。本文从皮肤“微环境污染”、过度氧化应激、“隐形损伤”、肠道菌群失衡等角度阐述了该病的发病机制,综述了细胞因子、高压氧、新材料、新药物应用等治疗研究进展,以期为该领域药物研发及临床治疗提供一定的理论基础及思路借鉴。

Diabetic nonhealing wounds are closely related to glycometabolism,which is a common clinical and intractable complication.Due to its complicated pathogenesis,safe and efficient treatments are still in needs.This article described its relevant pathogenesis,including"microenvironmental contamination",excessive oxidative stress,"hidden damage",and intestinal microbiological disorder,etc.In addition,the research progress of cytokines,hyperbaric oxygen,new materials and application of new drug were reviewed,in order to provide a theoretical basis for research and development of drugs and clinical treatment in this field.