“土当归”化学成分及药理作用研究进展

Research progress on chemical constituents and pharmacological activities of Angelica gigas Nakai

目的系统综述“土当归”(Angelica gigas Nakai,AGN)化学成分和药理作用的研究进展,为对其进一步深入研究和广泛使用奠定基础。方法查阅1959-2021年以来国内外相关文献63篇,进行分析和归纳总结。结果“土当归”作为我国朝鲜族常用草药,民间主要用于解毒和肿瘤治疗,现代研究表明其含有香豆素类、黄酮类、酚酸类、挥发油等化学成分,具有抗肿瘤、神经保护、免疫调节、抗菌、心脑血管保护等多重药理学活性。结论“土当归”具有较高的药用价值和广阔的开发前景,有待进一步深入研究。

Objective To summarize the chemical constituents and pharmacological effects of Angelica gigas Nakai(AGN)systematically,to lay a foundation for its in-depth research and extensive application.Methods A total of 63 relevant literatures at home and abroad from 1959 to 2021 were reviewed,analyzed and summarized.Results As a herbal medicine commonly used by the Chinese-Korean people,AGN is mainly used for detoxification and tumor treatment.Modern research shows that it contains coumarins,flavonoids,phenolic acids,volatile oils and other chemical constituents,and has multiple pharmacological activities such as anti-tumor,neuroprotection,immunoregulation,antibacterial and cardiovascular and cerebrovascular protection.Conclusion AGN has high medicinal value and broad research prospects,which need to be further studied.