运用数据挖掘技术分析中医美容外用方剂配伍规律

Analysis of Compatibility Rules of Chinese Medicine Cosmetic External Prescriptions by Data Mining Technology

目的:运用数据挖掘技术分析中医美容外用方剂的用药及配伍规律。方法:利用中国中医科学院中医药信息研究所开发的“中医经典方剂数据库”检索用于美白、祛斑、抗皱、治疗痤疮的中医美容相关外用方剂,使用数据挖掘插件,对4类功效的外用方剂所用的单味药进行出现频次的统计,应用关联规则分析药物配伍规律。结果:单味药的出现频次统计结果显示,白芷、白及、白蔹等药在4类美容外用方剂中均为高频用药。美白高频单味药还有白附子、白术、白茯苓等;祛斑高频单味药还有白丁香、密陀僧、防风等;抗皱高频单味药有苦杏仁、甘松、细辛等;治疗痤疮的高频单味药还有轻粉、牵牛子、硫黄等。关联规则的分析结果显示,美白的高重要性药物组合有白及-白蔹、白术-白檀香等;祛斑的高重要性药物组合有白芷-牵牛子、白及-白蔹等;抗皱的高重要性药物组合有甘松-楮实子、白茯苓-川芎等;治疗痤疮的高重要性药物组合有白附子-白蔹、苦杏仁-硫黄等。结论:外用方剂多通过熏洗、湿敷、涂抹、沐浴等形式进行用药,直接作用于患处。美白、祛斑、抗皱、治疗痤疮4类功效的外用方剂所用药物各有异同,以美白、润燥、清热、祛风药物为主,佐以芳香、攻毒杀虫、活血、化腐生肌之品。

Objective:To analyse the medication and compatibility rules of Chinese medicine cosmetic external prescriptions by data mining technology.Method:The Database of Chinese Medicine Classic Prescriptions established by the Institute of Information on Traditional Chinese Medicine was applied to retrieve external prescriptions related to Chinese medicine cosmetology for whitening,freckle removal,anti-wrinkle and treatment of acne;plug-in unit of data mining was used to count the occurrence frequency of single herbs used in external prescriptions with four kinds of effects respectively;the association rule is applied to analyze the compatibility rules of medicines.Results:The statistical results of occurrence frequency of single herbs showed that Radix Angelicae Dahuricae,Rhizoma Bletillae and Radix Ampelopsis were frequently used in the four kinds of cosmetic external prescriptions.The high-frequency single herbs for whitening included Rhizoma Typhonii,Rhizoma Atractylodis Macrocephalae,Poria,etc.;the high-frequency single herbs for freckle removal included Flos Caryophylli,Lithargyrum,Radix Saposhnikoviae,etc.;the high-frequency single herbs for anti-wrinkle included Semen Armeniacae Amarum,Radix et Rhizoma Nardostachyos,Radix et Rhizoma Asari,etc.;the high-frequency single herbs for the treatment of acne included Calomelas,Semen Pharbitidis,Sulphur,etc.The analysis of association rules showed that the high-importance drug combinations for whitening included Rhizoma Bletillae-Radix Ampelopsis,Rhizoma Atractylodis Macrocephalae-Lignum Santali Albi,etc.;the high-importance drug combinations for freckle removal included Radix Angelicae Dahuricae-Semen Pharbitidis,Rhizoma Bletillae-Radix Ampelopsis,etc.;the high-importance drug combinations for anti-wrinkle included Radix et Rhizoma Nardostachyos-Fructus Broussonetiae,Poria-Rhizoma Chuanxiong,etc.;the high-importance drug combinations for the treatment of acne included Rhizoma Typhonii-Radix Ampelopsis,Semen Armeniacae Amarum-Sulphur,etc.Conclusion:The external prescriptions are mainly used on the affected areas in the form of fumigation,wet compressing,smearing,bath,etc.The medicines used in external prescriptions for whitening,freckle removal,anti-wrinkle and treatment of acne have similarities and differences;the main medicines are those for whitening,moistening dryness,clearing heat and dispelling wind,accompanied by those for aroma,detoxicating and destroying parasites,invigorating blood,resolving putridity and regenerating tissue.