百合地黄汤联合氢溴酸伏硫西汀治疗抑郁症疗效观察及对应激反应的影响

Observation on Curative Effect of Baihe Dihuang Tang Combined with Voltioxetine Hydrobromide for Depression and Its Effect on Stress Response

目的:观察百合地黄汤联合氢溴酸伏硫西汀治疗抑郁症的临床疗效及对应激反应的影响。方法:选取84例抑郁症患者,按随机数字表法分为对照组和研究组各42例。对照组采用氢溴酸伏硫西汀治疗;研究组采用氢溴酸伏硫西汀联合百合地黄汤治疗。2组均以2个月为1个疗程,共治疗2个疗程。观察比较2组临床疗效,治疗前后的抑郁汉密尔顿量表(HAMD)评分、相关应激反应指标[血清皮质醇(CORT)、丙二醛(MDA)及超氧化物歧化酶(SOD)]水平变化。结果:研究组总有效率为95.2%,对照组为81.0%,2组比较,差异有统计学意义(P<0.05)。治疗1、2个疗程后,2组HAMD评分均较治疗前降低(P<0.05),且研究组在相同时间点的HAMD评分均低于对照组(P<0.05)。治疗2个疗程后,2组CORT、MDA水平均较治疗前降低(P<0.05),2组SOD水平均较治疗前升高(P<0.05);且研究组CORT、MDA水平均低于对照组(P<0.05),SOD水平高于对照组(P<0.05)。结论:给予抑郁症患者联合采用氢溴酸伏硫西汀及百合地黄汤治疗,可更显著改善抑郁症患者的临床症状,提高临床总有效率,缓解应激反应。

Objective:To observe the clinical effect of the therapy of Baihe Dihuang tang combined with voltioxetine hydrobromide on depression and its effect on stress response.Methods:A total of 84 patients with depression were selected and divided into the control group and the study group according to the random number table method,with 42 cases in each group.The control group was treated with voltioxetine hydrobromide,and the study group was treated with voltioxetine hydrobromide combined with Baihe Dihuang tang.Both groups were treated for two courses,two months being a course.The clinical effect,and the changes in the scores of Hamilton Depression Scale(HAMD)and levels of related stress response indexes,including serum cortisol(CORT),malondialdehyde(MDA)and superoxide dismutase(SOD)before and after treatment were observed and compared between the two groups.Results:The total effective rate was 95.2%in the study group and 81.0%in the control group,the difference being significant(P<0.05).After 1,2 courses of treatment,the HAMD scores in both groups were decreased when compared with those before treatment(P<0.05),and the HAMD score in the study group was lower than that in the control group at the same time point(P<0.05).After 2 courses of treatment,the levels of CORT and MDA in both groups were decreased when compared with those before treatment(P<0.05),and the levels of SOD in both groups were increased(P<0.05).The levels of CORT and MDA in the study group were lower than those in the control group(P<0.05),and the SOD level was higher than that in the control group(P<0.05).Conclusion:The combined treatment of voltioxetine hydrobromide and Baihe Dihuang tang can significantly improve the clinical symptoms of patients with depression,enhance the total effective rate of treatment and relieve stress response.