枳实薤白桂枝汤合小陷胸汤治疗痰热内阻型稳定型心绞痛临床研究

Clinical Study on Zhishi Xiebai Guizhi Tang and Xiao Xianxiong Tang for Stable Angina Pectoris of Phlegm-Heat Internal Obstruction Type

目的:观察枳实薤白桂枝汤合小陷胸汤治疗痰热内阻型稳定型心绞痛的临床疗效。方法:选取80例符合纳入标准及排除标准的痰热内阻型稳定型心绞痛患者,按照选取治疗方法分为2组,对照组35例予西医常规治疗,观察组45例在对照组治疗方案的基础上予枳实薤白桂枝汤合小陷胸汤治疗,2组均连续治疗4周。比较2组治疗前后中医证候评分、中医证候疗效,以及心绞痛疗效、硝酸甘油停减率。结果:治疗后,观察组胸痛、胸闷评分及中医证候总评分均低于对照组,并且中医证候疗效总有效率高于对照组,差异均有统计学意义(P<0.05)。心绞痛总有效率观察组86.67%,高于对照组65.71%,差异均有统计学意义(P<0.05)。观察组硝酸甘油停减率高于对照组,差异有统计学意义(P<0.05)。结论:枳实薤白桂枝汤合小陷胸汤用于痰热内阻型稳定型心绞痛患者,能显著提高治疗效果,改善患者临床症状,减少硝酸甘油的应用。

Objective:To observe the clinical effect of the therapy of Zhishi Xiebai Guizhi tang and Xiao Xianxiong tang on stable angina pectoris of phlegm-heat internal obstruction type.Methods:A total of 80 patients with stable angina pectoris that met the inclusion and exclusion criteria were selected and divided into two groups according to the selected treatment methods.The 35 cases in the control group were treated with conventional western medicine treatment,and the 45 cases in the observation group were additionally treated with Zhishi Xiebai Guizhi tang and Xiao Xianxiong tang based on the treatment of the control group.Both groups were treated for four weeks.The Chinese medicine syndrome scores,Chinese medicine syndrome effects,angina pectoris effects and stopping-or-reducing usage rates of the nitroglycerin before and after treatment were compared between the two groups.Results:After treatment,the scores of chest pain and chest oppression and the total score of Chinese medicine syndrome in the observation group were lower than those in the control group,and the total effective rate of Chinese medicine syndrome was higher than that in the control group,differences being significant(P<0.05).The total effective rate of angina pectoris was 86.67%in the observation group,higher than that of 65.71%in the control group,differences being significant(P<0.05).The stopping-or-reducing usage rate of nitroglycerin in the observation group was higher than that in the control group,the difference being significant(P<0.05).Conclusion:The therapy of Zhishi Xiebai Guizhi tang and Xiao Xianxiong tang can significantly improve the therapeutic effect,relieve the clinical symptoms and reduce the application of nitroglycerin in patients with stable angina pectoris of phlegm-heat internal obstruction type.