个体化经颅磁刺激治疗抑郁症的研究进展

Research progress of individualized transcranial magnetic stimulation in the treatment of depression

经颅磁刺激(TMS)是目前抑郁症物理治疗的常用方案,尽管其有效性和安全性已得到证实,但仍然有一部分患者TMS治疗效果不佳,由于个体大脑结构和功能具有高异质性,部分患者对传统定位和固定参数的TMS刺激不敏感。目前,神经影像技术和神经电生理技术已被应用于TMS刺激靶点的定位,以实现TMS治疗的个体化,提高抑郁症疗效。现对研究中的个体化治疗方案进行归纳总结,以期为TMS的临床精准治疗提供思路。

Transcranial magnetic stimulation(TMS),as a common therapeutic technique for major depression,has been fully confirmed regarding to its efficacy and safety.Whereas a proportion of patients with depression do not respond to standard TMS.This may be due to the high heterogeneity of individual brain structure and function in patients with depressive disorders,resulting in patients'insensitivity to TMS with traditional localization and fixed parameters.Currently,neuroimaging and neuro-electrophysiological techniques have been applied to the localization of TMS stimulation targets to realize the individualization of TMS treatment and improve the outcomes.This review summarizes the individualized treatment protocols in current studies,in order to provide ideas for the clinical precision treatment of TMS.