茵栀黄颗粒联合熊去氧胆酸胶囊治疗乙型病毒性肝炎的疗效观察

Efficacy of Yinzhihuang granules combined with ursodeoxycholic acid capsules in the treatment of virus hepatitis B

目的 观察茵栀黄颗粒联合熊去氧胆酸胶囊治疗乙型病毒性肝炎的临床疗效和安全性。方法 92例乙型病毒性肝炎患者随机分为对照组和观察组,每组46例,对照组采用熊去氧胆酸治疗,观察组采用茵栀黄颗粒联合熊去氧胆酸治疗,疗程均为4周。比较两组的临床疗效,治疗前后血清直接胆红素(DBIL)、总胆红素(TBIL)、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、谷氨酰基转移酶(GGT)等指标。结果 观察组临床疗效明显优于对照组(P<0.01)。治疗后,两组患者的DBIL、TBIL、ALT、AST、GGT水平均明显降低,且观察组变化更显著(P<0.01)。结论 茵栀黄颗粒联合熊去氧胆酸胶囊治疗乙型黄疸型病毒性肝炎疗效确切,能有效保护肝功能。

Objective To observe the clinical efficacy and safety of Yinzhihuang granules combined with ursodeoxycholic acid capsules in the treatment of viral hepatitis B. Methods A total of 92 patients with viral hepatitis B were randomly divided into the Control Group and the Observation Group, 46 cases in each group. The Control Group was treated with ursodeoxycholic acid while the Observation Group was treated with Yinzhihuang granules combined with ursodeoxycholic acid for 4 weeks.The clinical efficacy of the two groups were compared. DBIL, TBIL, ALT, AST, and GGT of the two groups before and after treatment were compared. Results The clinical effect of the Observation Group was superior to that of the Control Group(P<0.01). After treatment, the levels of DBIL, TBIL, ALT, AST and GGT in 2 groups were significantly decreased, and the changes in the Observation Group were more significant(P<0.01). Conclusion The combination of Yinzhihuang granules with ursodeoxycholic acid capsule is effective in the treatment of jaundice viral hepatitis B and can effectively protect liver function.