mRNA疫苗的研究进展

Progress in research on mRNA vaccines

近年来随着生物技术的发展,疫苗的研发策略不再仅限于传统的疫苗,曾经被认为有较多局限性的mRNA疫苗在通过一系列研究和改进后,表现出其优越性的一面,已经在肿瘤、感染性疾病及自身免疫性疾病的防控和治疗等方面展示出了良好的应用前景。本文对mRNA疫苗的结构设计和优化及传递系统和疾病防治应用方面取得的进展作一综述。

With the development of biotechnology,the development strategy of vaccines is no longer limited to that of traditional vaccines.The mRNA vaccines,which were once considered to have multiple limitations,have shown their advantages after a series of structural modifications as well as a good application prospect in the prevention,control and treatment of tumors,infectious diseases and autoimmune diseases.This paper reviews the progress in research on structural design and optimization,delivery system and applications in prevention and control of diseases of mRNA vaccines.