溃疡性结肠炎特色病机“浊毒损膜伤络”及其意义

Discussion on the Characteristic Pathogeneses of Ulcerative Colitis"Turbid Poison Damage to Membrane and Collateral"and Its Significance

溃疡性结肠炎(UC)是一种病因不明的结肠和直肠的慢性非特异性炎症性疾病,发病率逐渐升高,现代医学治疗效果欠佳,已成为临床难治疾病之一。在“浊毒理论”的指导下,笔者团队提出UC浊毒致病的病机,结合UC的现代发病机制,总结其病机为——浊毒损膜伤络,其是UC反复发作、缠绵难愈的关键;并且进一步提出“肠黏膜屏障损伤、免疫功能紊乱、细胞凋亡或细胞焦亡、神经内分泌功能失调”是该病机的现代生物学基础,它能客观化、具体化、定量化阐述中医病机的现代科学内涵,使浊毒理论在UC防治中发挥更加重要的作用。

Ulcerative colitis(UC)is a chronic non-specific inflammatory disease of colon and rectum with unknown etiology.Its incidence is gradually increasing,and modern medical treatment is not effective enough.It has become one of the refractory diseases clinically.Under the guidance of the"turbid poison theory",the pathogeneses of ulcerative colitis were proposed.Combined with the modern pathogeneses of UC,the pathogenesis was summarized as turbid poison damage to the membrane and collaterals,which was the key to the recurrence and lingering difficulty in healing UC.Furthermore,intestinal mucosal barrier injury,immune dysfunction,apoptosis or pyroptosis,neuroendocrine dysfunction are modern biological bases of its pathogeneses.And it could objectively,concretely and quantitatively explain modern scientific connotations of TCM pathogeneses,and make turbid poison theory play a more important role in UC prevention and treatment.