地龙化学成分及药理活性研究进展

Research development of Pheretima on chemical composition and pharmacological activity

地龙是传统中药,具有清热定惊、通络、平喘等功效,临床常用于治疗高热神昏、肺热咳喘、半身不遂等。地龙所含化学成分众多,其中氨基酸类、多肽类、核苷类和有机酸等类化合物为其主要活性成分。现代药理研究表明地龙具有抗炎、抗血栓、心脏保护、抗肿瘤和改善呼吸系统功能等作用。总结了近年来国内外有关地龙化学成分、药理活性相关文献,对其研究进展进行综述,为地龙的药物开发及临床应用提供依据。

Pheretima is a traditional Chinese medicine. It has the effects of clearing heat, calming convulsion, unblocking collaterals and relieving asthma. It is often used clinically for the treatment of high fever, dizziness, lung heat, cough asthma and hemiplegia.Pheretima contains many chemical components, among which amino acids, polypeptides, nucleosides and organic acids are the main ingredients. Modern pharmacological studies showed that Pheretima has anti-inflammatory, antithrombosis, cardioprotection, antitumor and respiratory system improvement effects. This article summarizes the research progress on chemical components and pharmacology of Pheretima in recent years for providing a basis for pheretima drug development and clinical application.